Literature DB >> 9241632

Characterization of hypertensive and hypotensive inbred strains of mice.

G Schlager1, J Sides.   

Abstract

The hypertensive inbred mouse strain, BPH/2, has high blood pressure early in life, compared with its hypotensive BPL/1 and normotensive BPN/3 controls. At 21 weeks of age, the hypertensive mouse has a systolic blood pressure 60 mm Hg higher than that of the hypotensive mouse. The difference in blood pressure between hypertensive and hypotensive mice is associated with strain differences in heart rate, heart weight, relative heart weight, left ventricular mass, kidney weight, and hematocrit. These strains have been inbred by brother x sister matings for nearly 50 generations in the BPH/2 and BPL/1 strains, and for nearly 40 generations in the BPN/3 strain.

Entities:  

Mesh：

Year:  1997        PMID： 9241632

Source DB:  PubMed          Journal:  Lab Anim Sci        ISSN： 0023-6764


  30 in total

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4.  Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension.

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5.  Differential hypertensive protease expression in the thoracic versus abdominal aorta.

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6.  De novo expression of Kv6.3 contributes to changes in vascular smooth muscle cell excitability in a hypertensive mice strain.

Authors:  Alejandro Moreno-Domínguez; Pilar Cidad; Eduardo Miguel-Velado; José R López-López; M Teresa Pérez-García
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Review 8.  Preeclampsia, of mice and women.

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10.  Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle.

Authors:  Sendoa Tajada; Pilar Cidad; Olaia Colinas; L Fernando Santana; José R López-López; M Teresa Pérez-García
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