OBJECTIVE: To test the hypothesis that dysphoric and non-dysphoric types of CD could be distinguished from one another in their patterns of familiality, adversity, and comorbidity. METHODS: We examined 140 ADHD and 120 normal controls at baseline and 4 years later using assessments from multiple domains. We compared ADHD subgroups with and without conduct (CD) and bipolar (BPD) disorders on psychiatric outcomes at a 4-year follow-up, familial psychopathology and psychosocial functioning. RESULTS: We found that ADHD children with both disorders had higher familial and personal risk for mood disorders than those with CD only, who had a higher personal risk for antisocial personality disorder. Among ADHD probands, having both CD and BPD was associated with poorer functioning and an increased risk for psychiatric hospitalization. DISCUSSION: Although preliminary, our findings suggest that the distinction between dysphoric and non-dysphoric CD may be clinically meaningful. If confirmed, our findings could have important diagnostic and therapeutic implications for the management of antisocial youth.
OBJECTIVE: To test the hypothesis that dysphoric and non-dysphoric types of CD could be distinguished from one another in their patterns of familiality, adversity, and comorbidity. METHODS: We examined 140 ADHD and 120 normal controls at baseline and 4 years later using assessments from multiple domains. We compared ADHD subgroups with and without conduct (CD) and bipolar (BPD) disorders on psychiatric outcomes at a 4-year follow-up, familial psychopathology and psychosocial functioning. RESULTS: We found that ADHDchildren with both disorders had higher familial and personal risk for mood disorders than those with CD only, who had a higher personal risk for antisocial personality disorder. Among ADHD probands, having both CD and BPD was associated with poorer functioning and an increased risk for psychiatric hospitalization. DISCUSSION: Although preliminary, our findings suggest that the distinction between dysphoric and non-dysphoric CD may be clinically meaningful. If confirmed, our findings could have important diagnostic and therapeutic implications for the management of antisocial youth.
Authors: Joseph Biederman; Marykate Martelon; Stephen V Faraone; K Yvonne Woodworth; Thomas J Spencer; Janet R Wozniak Journal: J Affect Disord Date: 2012-11-17 Impact factor: 4.839
Authors: J Wozniak; T Wilens; M DiSalvo; A Farrell; R Wolenski; S V Faraone; J Biederman Journal: Acta Psychiatr Scand Date: 2019-03-18 Impact factor: 6.392
Authors: Timothy E Wilens; Joseph Biederman; MaryKate Martelon; Courtney Zulauf; Jesse P Anderson; Nicholas W Carrellas; Amy Yule; Janet Wozniak; Ronna Fried; Stephen V Faraone Journal: J Clin Psychiatry Date: 2016-10 Impact factor: 4.384
Authors: Timothy E Wilens; Joseph Biederman; Joel J Adamson; Aude Henin; Stephanie Sgambati; Martin Gignac; Robert Sawtelle; Alison Santry; Michael C Monuteaux Journal: Drug Alcohol Depend Date: 2008-03-17 Impact factor: 4.492
Authors: Jérôme Endrass; Stefan Vetter; Alex Gamma; William T Gallo; Astrid Rossegger; Frank Urbaniok; Jules Angst Journal: Eur Arch Psychiatry Clin Neurosci Date: 2007-02-07 Impact factor: 5.270
Authors: Joseph Biederman; Carter R Petty; Michael C Monuteaux; Margaret Evans; Tiffany Parcell; Stephen V Faraone; Janet Wozniak Journal: J Clin Psychiatry Date: 2009-04-21 Impact factor: 4.384