J Wozniak1,2, T Wilens1,2, M DiSalvo1, A Farrell1, R Wolenski1, S V Faraone3, J Biederman1,2. 1. Pediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, MA, USA. 2. Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 3. Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Abstract
OBJECTIVE: To investigate the association between pediatric bipolar I (BP-I) disorder and conduct disorder (CD) using familial risk analysis. METHOD: We compared diagnoses in relatives of youth in four proband groups defined by the presence or absence of BP-I and CD: (1) probands with neither CD nor BP-I (probands: N = 550; relatives: N = 1656), (2) probands with CD and without BP-I (probands: N = 40; relatives: N = 127), (3) probands with BP-I and without CD (probands: N = 197; relatives: N = 579), and (4) probands with both CD and BP-I (probands: N = 176; relatives: N = 488). All subjects were evaluated with structured diagnostic interviews, and diagnoses of relatives were made blind to the diagnoses of probands. RESULTS: Relatives of probands with BP-I disorder had high rates of BP-I, and relatives of probands with CD had high rates of CD irrespective of the comorbidity with the other disorder. Relatives of probands with the combined condition of CD and BP-I had high rates of the combined condition. CONCLUSION: The finding of cosegregation between BP-I disorder and CD is consistent with the hypothesis that the combined condition represents a distinct subtype of either disorder.
OBJECTIVE: To investigate the association between pediatric bipolar I (BP-I) disorder and conduct disorder (CD) using familial risk analysis. METHOD: We compared diagnoses in relatives of youth in four proband groups defined by the presence or absence of BP-I and CD: (1) probands with neither CD nor BP-I (probands: N = 550; relatives: N = 1656), (2) probands with CD and without BP-I (probands: N = 40; relatives: N = 127), (3) probands with BP-I and without CD (probands: N = 197; relatives: N = 579), and (4) probands with both CD and BP-I (probands: N = 176; relatives: N = 488). All subjects were evaluated with structured diagnostic interviews, and diagnoses of relatives were made blind to the diagnoses of probands. RESULTS: Relatives of probands with BP-I disorder had high rates of BP-I, and relatives of probands with CD had high rates of CD irrespective of the comorbidity with the other disorder. Relatives of probands with the combined condition of CD and BP-I had high rates of the combined condition. CONCLUSION: The finding of cosegregation between BP-I disorder and CD is consistent with the hypothesis that the combined condition represents a distinct subtype of either disorder.
Authors: Melissa A Brotman; Layla Kassem; Michelle M Reising; Amanda E Guyer; Daniel P Dickstein; Brendan A Rich; Kenneth E Towbin; Daniel S Pine; Francis J McMahon; Ellen Leibenluft Journal: Am J Psychiatry Date: 2007-08 Impact factor: 18.112
Authors: Joseph Biederman; Michael C Monuteaux; Eric Mick; Thomas Spencer; Timothy E Wilens; Kristy L Klein; Julia E Price; Stephen V Faraone Journal: Biol Psychiatry Date: 2006-05-19 Impact factor: 13.382
Authors: J E Cueva; J E Overall; A M Small; J L Armenteros; R Perry; M Campbell Journal: J Am Acad Child Adolesc Psychiatry Date: 1996-04 Impact factor: 8.829
Authors: Timothy E Wilens; Joseph Biederman; Joel J Adamson; Aude Henin; Stephanie Sgambati; Martin Gignac; Robert Sawtelle; Alison Santry; Michael C Monuteaux Journal: Drug Alcohol Depend Date: 2008-03-17 Impact factor: 4.492
Authors: Jonathan L Hess; Nicholas H Nguyen; Jesse Suben; Ryan M Meath; Avery B Albert; Sarah Van Orman; Kristin M Anders; Patricia J Forken; Cheryl A Roe; Thomas G Schulze; Stephen V Faraone; Stephen J Glatt Journal: Transl Psychiatry Date: 2020-09-23 Impact factor: 6.222