PURPOSE: To compare resultant lung dose from proton arc therapy of the chest wall to that from electron arc therapy. METHODS AND MATERIALS: A 200 MeV proton beam from the Indiana University Cyclotron was range shifted and modulated to provide a spread out Bragg peak extending from the surface to a depth of 4 cm in water. The chest wall of an Alderson Rando phantom was irradiated by this beam, collimated to a 20 x 4 cm field size, while it rotated on a platform at approximately 1 rpm. For comparison, electron arc therapy of the Rando phantom chest wall was similarly performed with 12 MeV electrons and the resultant lung dose measured in each case. RESULTS: Dose-volume histograms for the Rando phantom left lung indicate a reduced volume of irradiated lung for protons at all dose levels and an integral lung dose that is half that for electron arc therapy in the case studied. In addition, a more uniform dose coverage of the target volume was achieved with the proton therapy. CONCLUSION: This study demonstrates a potential role for proton arc therapy as an alternative to electron arc therapy when lung dose must be minimized.
PURPOSE: To compare resultant lung dose from proton arc therapy of the chest wall to that from electron arc therapy. METHODS AND MATERIALS: A 200 MeV proton beam from the Indiana University Cyclotron was range shifted and modulated to provide a spread out Bragg peak extending from the surface to a depth of 4 cm in water. The chest wall of an Alderson Rando phantom was irradiated by this beam, collimated to a 20 x 4 cm field size, while it rotated on a platform at approximately 1 rpm. For comparison, electron arc therapy of the Rando phantom chest wall was similarly performed with 12 MeV electrons and the resultant lung dose measured in each case. RESULTS: Dose-volume histograms for the Rando phantom left lung indicate a reduced volume of irradiated lung for protons at all dose levels and an integral lung dose that is half that for electron arc therapy in the case studied. In addition, a more uniform dose coverage of the target volume was achieved with the proton therapy. CONCLUSION: This study demonstrates a potential role for proton arc therapy as an alternative to electron arc therapy when lung dose must be minimized.
Authors: Laura A Rechner; Rebecca M Howell; Rui Zhang; Carol Etzel; Andrew K Lee; Wayne D Newhauser Journal: Phys Med Biol Date: 2012-10-10 Impact factor: 3.609
Authors: Wayne D Newhauser; Rui Zhang; Timothy G Jones; Annelise Giebeler; Phillip J Taddei; Robert D Stewart; Andrew Lee; Oleg Vassiliev Journal: Cancers (Basel) Date: 2015-04-24 Impact factor: 6.639