Literature DB >> 9236896

Histamine content in colorectal cancer. Are there sufficient levels of histamine to affect lymphocyte function?

J L Reynolds1, J Akhter, W J Adams, D L Morris.   

Abstract

Histamine has been found to stimulate growth of colorectal cancer in vitro and in vivo. Histamine has also been found to inhibit lymphocyte activity in vitro at concentrations greater than 10(-7) M. The aim of our study was to determine if the histamine concentrations in human colorectal cancer were sufficient to achieve these effects. We measured the histamine content in 31 colorectal cancer specimens using a radioenzymatic assay. Results were expressed as microgram histamine per gram of fresh tissue weight. Recovery and reproducibility studies were also carried out. The median histamine concentration in colorectal cancer tissue was 8.4 micrograms/g [7.6 x 10(-5)M], ranging from 0.3 microgram/g to 20.6 micrograms/g. The high concentration of histamine in colon cancer is enough to be locally immunosuppressive.

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Year:  1997        PMID： 9236896     DOI： 10.1016/s0748-7983(97)92388-x

Source DB:  PubMed          Journal:  Eur J Surg Oncol        ISSN： 0748-7983            Impact factor:   4.424


  8 in total

1.  Histamine reduces susceptibility to natural killer cells via down-regulation of NKG2D ligands on human monocytic leukaemia THP-1 cells.

Authors:  Yasuhiro Nagai; Yukinori Tanaka; Toshinobu Kuroishi; Ryutaro Sato; Yasuo Endo; Shunji Sugawara
Journal:  Immunology       Date:  2012-05       Impact factor: 7.397

Review 2.  Histamine receptors and cancer pharmacology: an update.

Authors:  Noelia A Massari; Melisa B Nicoud; Vanina A Medina
Journal:  Br J Pharmacol       Date:  2018-12-13       Impact factor: 8.739

Review 3.  Histamine receptors and cancer pharmacology.

Authors:  Vanina A Medina; Elena S Rivera
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

4.  Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells.

Authors:  Xiang Dong Yang; Walden Ai; Samuel Asfaha; Govind Bhagat; Richard A Friedman; Guangchun Jin; Heuijoon Park; Benjamin Shykind; Thomas G Diacovo; Andras Falus; Timothy C Wang
Journal:  Nat Med       Date:  2010-12-19       Impact factor: 53.440

5.  Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression.

Authors:  Zhengyu Fang; Wantong Yao; Yi Xiong; Jiana Li; Li Liu; Lei Shi; Wei Zhang; Chao Zhang; Liping Nie; Jun Wan
Journal:  BMC Cancer       Date:  2011-05-24       Impact factor: 4.430

6.  Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect--a histopathological and immunohistochemical study.

Authors:  I D Nagtegaal; C A Marijnen; E K Kranenbarg; A Mulder-Stapel; J Hermans; C J van de Velde; J H van Krieken
Journal:  BMC Cancer       Date:  2001-07-16       Impact factor: 4.430

7.  Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.

Authors:  Yi Wang; Yang Jiang; Jun-Ichiro Ikeda; Tian Tian; Atsushi Sato; Hiroshi Ohtsu; Eiichi Morii
Journal:  Cancer Med       Date:  2014-07-10       Impact factor: 4.452

Review 8.  Histamine in cancer immunology and immunotherapy. Current status and new perspectives.

Authors:  María de la Paz Sarasola; Mónica A Táquez Delgado; Melisa B Nicoud; Vanina A Medina
Journal:  Pharmacol Res Perspect       Date:  2021-10
  8 in total

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