BACKGROUND: Induction chemoradiotherapy followed by esophagectomy may provide results superior to those of single-modality treatment in patients with esophageal cancer. The purpose of this study was to review our experience with this approach for esophageal cancer. METHODS: From 1988 to 1996, 166 consecutive patients with esophageal cancer were evaluated; 66 entered a protocol of chemotherapy (5-fluorouracil, cisplatin) concurrent with radiation (45 Gy) followed by esophagectomy. Fifty-four patients completed the protocol. RESULTS: Toxicity associated with induction chemoradiotherapy was minimal. The actuarial survival at 12, 24, and 36 months was 59%, 42%, and 32%, respectively. The pathologic complete response (pCR) rate was 41%, with 12-, 24-, and 36-month survivals of 77%, 50%, and 45%, whereas non-pCR patients had survivals of 46%, 35%, and 23%. The difference in survival between pCR and non-pCR patients was not significant (p = 0.13), but the difference in recurrence-free survival was significant (p = 0.007). CONCLUSIONS: This well-tolerated protocol resulted in a high pCR. Trimodality treatment for esophageal cancer may provide long-term survival in some patients regardless of their pCR status.
BACKGROUND: Induction chemoradiotherapy followed by esophagectomy may provide results superior to those of single-modality treatment in patients with esophageal cancer. The purpose of this study was to review our experience with this approach for esophageal cancer. METHODS: From 1988 to 1996, 166 consecutive patients with esophageal cancer were evaluated; 66 entered a protocol of chemotherapy (5-fluorouracil, cisplatin) concurrent with radiation (45 Gy) followed by esophagectomy. Fifty-four patients completed the protocol. RESULTS:Toxicity associated with induction chemoradiotherapy was minimal. The actuarial survival at 12, 24, and 36 months was 59%, 42%, and 32%, respectively. The pathologic complete response (pCR) rate was 41%, with 12-, 24-, and 36-month survivals of 77%, 50%, and 45%, whereas non-pCR patients had survivals of 46%, 35%, and 23%. The difference in survival between pCR and non-pCR patients was not significant (p = 0.13), but the difference in recurrence-free survival was significant (p = 0.007). CONCLUSIONS: This well-tolerated protocol resulted in a high pCR. Trimodality treatment for esophageal cancer may provide long-term survival in some patients regardless of their pCR status.
Authors: A William Blackstock; Mabea Aklilu; James Lovato; Michael R Farmer; Girish Mishra; Susan A Melin; Timothy Oaks; Kim Geisinger; Edward A Levine Journal: Int J Gastrointest Cancer Date: 2006
Authors: Nicolas Plaisant; Pierre Senesse; David Azria; Claire Lemanski; Marc Ychou; Francois Quenet; Bernard Saint-Aubert; Philippe Rouanet Journal: World J Surg Date: 2005-01 Impact factor: 3.352
Authors: Pooja R Rohatgi; Stephen G Swisher; Arlene M Correa; Tsung-T Wu; Zhongxing Liao; Garrett L Walsh; Ara A Vaporciyan; David C Rice; Norio Fukami; Jack A Roth; Jaffer A Ajani Journal: Int J Gastrointest Cancer Date: 2005
Authors: A C Lockhart; C E Reed; P A Decker; B F Meyers; M K Ferguson; A R Oeltjen; J B Putnam; S D Cassivi; A J Montero; T E Schefter Journal: Ann Oncol Date: 2014-02-20 Impact factor: 32.976
Authors: Ann Driessen; Willy Landuyt; Sylvia Pastorekova; Johnny Moons; Laurence Goethals; Karin Haustermans; Philippe Nafteux; Freddy Penninckx; Karel Geboes; Toni Lerut; Nadine Ectors Journal: Ann Surg Date: 2006-03 Impact factor: 12.969
Authors: Cuong P Duong; Rodney J Hicks; Leann Weih; Elizabeth Drummond; Trevor Leong; Michael Michael; Robert J S Thomas Journal: Eur J Nucl Med Mol Imaging Date: 2006-03-21 Impact factor: 9.236