Literature DB >> 9232480

Autism and the immune system.

T van Gent1, C J Heijnen, P D Treffers.   

Abstract

As our knowledge of the interactions of the immune, nervous and endocrine systems progresses, complex links with the origin and course of psychopathology in childhood are revealed. In this article the neuroimmunological literature on autism is reviewed. Relevant aspects of immune functioning and the neuroendocrine-immune network are described. We present the immunological findings in autistic patients within two related conceptual frameworks: a viral and an autoimmune hypothesis. Interpretation of data is hampered by conceptual and methodological differences between studies. Both the clinical significance of the immune changes and the causal connection between immune changes and psychopathological phenomena in autism remain to be elucidated. Recommendations for further research are given.

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Year:  1997        PMID： 9232480     DOI： 10.1111/j.1469-7610.1997.tb01518.x

Source DB:  PubMed          Journal:  J Child Psychol Psychiatry        ISSN： 0021-9630            Impact factor:   8.982


  26 in total

1.  Exclusion of linkage to the HLA region in ninety multiplex sibships with autism.

Authors:  T Rogers; L Kalaydjieva; J Hallmayer; P B Petersen; P Nicholas; C Pingree; W M McMahon; D Spiker; L Lotspeich; H Kraemer; P McCague; S Dimiceli; N Nouri; T Peachy; J Yang; D Hinds; N Risch; R M Myers
Journal:  J Autism Dev Disord       Date:  1999-06

Review 2.  The neurobiology of autism: new pieces of the puzzle.

Authors:  Maria T Acosta; Phillip L Pearl
Journal:  Curr Neurol Neurosci Rep       Date:  2003-03       Impact factor: 5.081

3.  Macrophage migration inhibitory factor and autism spectrum disorders.

Authors:  Elena L Grigorenko; Summer S Han; Carolyn M Yrigollen; Lin Leng; Yuka Mizue; George M Anderson; Erik J Mulder; Annelies de Bildt; Ruud B Minderaa; Fred R Volkmar; Joseph T Chang; Richard Bucala
Journal:  Pediatrics       Date:  2008-08       Impact factor: 7.124

4.  Immune deficiency influences juvenile social behavior and maternal behavior.

Authors:  Kayla M Quinnies; Kimberly H Cox; Emilie F Rissman
Journal:  Behav Neurosci       Date:  2015-06       Impact factor: 1.912

5.  Immune Alterations in CD8+ T Cells Are Associated with Neuronal C-C and C-X-C Chemokine Receptor Regulation Through Adenosine A2A Receptor Signaling in a BTBR T+ Itpr3tf/J Autistic Mouse Model.

Authors:  Sheikh F Ahmad; Mushtaq A Ansari; Ahmed Nadeem; Saleh A Bakheet; Raish Mohammad; Sabry M Attia
Journal:  Mol Neurobiol       Date:  2017-04-18       Impact factor: 5.590

Review 6.  The promise and the pitfalls of autism research: an introductory note for new autism researchers.

Authors:  David G Amaral
Journal:  Brain Res       Date:  2010-12-01       Impact factor: 3.252

7.  Detecting maternal-fetal genotype interactions associated with conotruncal heart defects: a haplotype-based analysis with penalized logistic regression.

Authors:  Ming Li; Stephen W Erickson; Charlotte A Hobbs; Jingyun Li; Xinyu Tang; Todd G Nick; Stewart L Macleod; Mario A Cleves
Journal:  Genet Epidemiol       Date:  2014-03-02       Impact factor: 2.135

8.  A double-blind, placebo-controlled trial of oral human immunoglobulin for gastrointestinal dysfunction in children with autistic disorder.

Authors:  Benjamin L Handen; Raun D Melmed; Robin L Hansen; Michael G Aman; David L Burnham; Jon B Bruss; Christopher J McDougle
Journal:  J Autism Dev Disord       Date:  2009-01-16

9.  Pathogenesis of autism: a patchwork of genetic causes.

Authors:  Elena L Grigorenko
Journal:  Future Neurol       Date:  2009

10.  Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease.

Authors:  Aristo Vojdani; Mohsen Bazargan; Elroy Vojdani; John Samadi; Alen A Nourian; Navid Eghbalieh; Edwin L Cooper
Journal:  Clin Diagn Lab Immunol       Date:  2004-05
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