Literature DB >> 21129367

The promise and the pitfalls of autism research: an introductory note for new autism researchers.

David G Amaral1.   

Abstract

The last decade has seen an enormous growth in the quantity of research directed at understanding the biological underpinnings of autism spectrum disorders. This increase has been spurred on, in part, by research funding provided through private, parent advocacy groups. While increased funding and entry into autism research by scientists from many disciplines has facilitated the speed of discoveries germane to establishing the etiologies of autism, there remain a number of roadblocks to understanding autism sufficiently well to foster new treatments. This short article provides a brief overview of some of the achievements and some of the difficulties in conducting autism research.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID: 21129367      PMCID: PMC3307796          DOI: 10.1016/j.brainres.2010.11.077

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  47 in total

Review 1.  Immune signalling in neural development, synaptic plasticity and disease.

Authors:  Lisa M Boulanger; Carla J Shatz
Journal:  Nat Rev Neurosci       Date:  2004-07       Impact factor: 34.870

2.  Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years.

Authors:  Heather Cody Hazlett; Michele Poe; Guido Gerig; Rachel Gimpel Smith; James Provenzale; Allison Ross; John Gilmore; Joseph Piven
Journal:  Arch Gen Psychiatry       Date:  2005-12

Review 3.  Behavioural phenotyping assays for mouse models of autism.

Authors:  Jill L Silverman; Mu Yang; Catherine Lord; Jacqueline N Crawley
Journal:  Nat Rev Neurosci       Date:  2010-07       Impact factor: 34.870

4.  The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages.

Authors:  Cynthia Mills Schumann; Julia Hamstra; Beth L Goodlin-Jones; Linda J Lotspeich; Hower Kwon; Michael H Buonocore; Cathy R Lammers; Allan L Reiss; David G Amaral
Journal:  J Neurosci       Date:  2004-07-14       Impact factor: 6.167

5.  Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism.

Authors:  Heather Cody Hazlett; Michele D Poe; Amy A Lightbody; Guido Gerig; James R Macfall; Allison K Ross; James Provenzale; Arianna Martin; Allan L Reiss; Joseph Piven
Journal:  J Neurodev Disord       Date:  2009-03       Impact factor: 4.025

Review 6.  Mouse behavioral assays relevant to the symptoms of autism.

Authors:  Jacqueline N Crawley
Journal:  Brain Pathol       Date:  2007-10       Impact factor: 6.508

7.  What are infant siblings teaching us about autism in infancy?

Authors:  Sally J Rogers
Journal:  Autism Res       Date:  2009-06       Impact factor: 5.216

Review 8.  A synaptic trek to autism.

Authors:  Thomas Bourgeron
Journal:  Curr Opin Neurobiol       Date:  2009-06-21       Impact factor: 6.627

9.  Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology.

Authors:  Paul Ashwood; Andrew Anthony; Alicia A Pellicer; Franco Torrente; John A Walker-Smith; Andrew J Wakefield
Journal:  J Clin Immunol       Date:  2003-11       Impact factor: 8.317

10.  Prenatal and perinatal risk factors for autism in China.

Authors:  Xin Zhang; Cong-Chao Lv; Jiang Tian; Ru-Juan Miao; Wei Xi; Irva Hertz-Picciotto; Lihong Qi
Journal:  J Autism Dev Disord       Date:  2010-11
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  26 in total

Review 1.  Maternal SSRIs experience and risk of ASD in offspring: a review.

Authors:  Zainab Fatima; Aqeela Zahra; Maria Ghouse; Xu Wang; Zonghui Yuan
Journal:  Toxicol Res (Camb)       Date:  2018-07-11       Impact factor: 3.524

2.  Does the human gut microbiota contribute to the etiology of autism spectrum disorders?

Authors:  Petra Louis
Journal:  Dig Dis Sci       Date:  2012-08       Impact factor: 3.199

3.  Salience network-based classification and prediction of symptom severity in children with autism.

Authors:  Lucina Q Uddin; Kaustubh Supekar; Charles J Lynch; Amirah Khouzam; Jennifer Phillips; Carl Feinstein; Srikanth Ryali; Vinod Menon
Journal:  JAMA Psychiatry       Date:  2013-08       Impact factor: 21.596

Review 4.  Changing concepts and findings on autism.

Authors:  Michael Rutter
Journal:  J Autism Dev Disord       Date:  2013-08

Review 5.  Face processing in autism spectrum disorders: From brain regions to brain networks.

Authors:  Jason S Nomi; Lucina Q Uddin
Journal:  Neuropsychologia       Date:  2015-03-28       Impact factor: 3.139

6.  Hyperexcitability and Hyperplasticity Disrupt Cerebellar Signal Transfer in the IB2 KO Mouse Model of Autism.

Authors:  Teresa Soda; Lisa Mapelli; Francesca Locatelli; Laura Botta; Mitchell Goldfarb; Francesca Prestori; Egidio D'Angelo
Journal:  J Neurosci       Date:  2019-01-29       Impact factor: 6.167

Review 7.  Does microglial dysfunction play a role in autism and Rett syndrome?

Authors:  Izumi Maezawa; Marco Calafiore; Heike Wulff; Lee-Way Jin
Journal:  Neuron Glia Biol       Date:  2012-04-30

8.  Brain hyperconnectivity in children with autism and its links to social deficits.

Authors:  Kaustubh Supekar; Lucina Q Uddin; Amirah Khouzam; Jennifer Phillips; William D Gaillard; Lauren E Kenworthy; Benjamin E Yerys; Chandan J Vaidya; Vinod Menon
Journal:  Cell Rep       Date:  2013-11-07       Impact factor: 9.423

9.  Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology.

Authors:  Bharathi S Gadad; Wenhao Li; Umar Yazdani; Stephen Grady; Trevor Johnson; Jacob Hammond; Howard Gunn; Britni Curtis; Chris English; Vernon Yutuc; Clayton Ferrier; Gene P Sackett; C Nathan Marti; Keith Young; Laura Hewitson; Dwight C German
Journal:  Proc Natl Acad Sci U S A       Date:  2015-09-28       Impact factor: 11.205

10.  Parsing brain structural heterogeneity in males with autism spectrum disorder reveals distinct clinical subtypes.

Authors:  Heng Chen; Lucina Q Uddin; Xiaonan Guo; Jia Wang; Runshi Wang; Xiaomin Wang; Xujun Duan; Huafu Chen
Journal:  Hum Brain Mapp       Date:  2018-09-25       Impact factor: 5.038

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