OBJECTIVE: To study the value of surgical treatment in patients with potentially resectable gallbladder cancer. DESIGN: Prospective non-randomised study. SETTING: University hospital, Chile. SUBJECTS: 109 Patients with gallbladder cancers, most of which were detected in the cholecystectomy specimen. INTERVENTIONS: 53 Patients underwent reoperation with the aim of doing a lymphadenectomy and resecting the gallbladder bed. MAIN OUTCOME MEASURES: Morbidity and short and long term mortality RESULTS: Residual tumour after cholecystectomy was mainly observed in patients with serosal and adipose tissue infiltration. Lymph nodes and liver invasion were associated with recurrence. Survival analysis was focused on the group with subserosal infiltration because it is the largest subgroup in this study and prognosis is intermediate. Patients who underwent curative resection had a significantly better survival than those treated by simple cholecystectomy (p = 0.005). CONCLUSIONS: Extended cholecystectomy improved the prognosis of patients whose cancers were restricted to the subserosal layer. Additional treatments are necessary to improve the results obtained with operation alone.
OBJECTIVE: To study the value of surgical treatment in patients with potentially resectable gallbladder cancer. DESIGN: Prospective non-randomised study. SETTING: University hospital, Chile. SUBJECTS: 109 Patients with gallbladder cancers, most of which were detected in the cholecystectomy specimen. INTERVENTIONS: 53 Patients underwent reoperation with the aim of doing a lymphadenectomy and resecting the gallbladder bed. MAIN OUTCOME MEASURES: Morbidity and short and long term mortality RESULTS: Residual tumour after cholecystectomy was mainly observed in patients with serosal and adipose tissue infiltration. Lymph nodes and liver invasion were associated with recurrence. Survival analysis was focused on the group with subserosal infiltration because it is the largest subgroup in this study and prognosis is intermediate. Patients who underwent curative resection had a significantly better survival than those treated by simple cholecystectomy (p = 0.005). CONCLUSIONS: Extended cholecystectomy improved the prognosis of patients whose cancers were restricted to the subserosal layer. Additional treatments are necessary to improve the results obtained with operation alone.
Authors: Mia S DeSimone; Michael Goodman; Burcin Pehlivanoglu; Bahar Memis; Serdar Balci; Juan Carlos Roa; Kee-Taek Jang; Jin-Young Jang; Seung-Mo Hong; Kyoungbun Lee; Haeryoung Kim; Hye-Jeong Choi; Takashi Muraki; Juan Carlos Araya; Enrique Bellolio; Juan M Sarmiento; Shishir K Maithel; Hector F Losada; Olca Basturk; Michelle D Reid; Jill Koshiol; Volkan Adsay Journal: Virchows Arch Date: 2021-01-07 Impact factor: 4.064
Authors: Jong Hee Yoon; Young Joo Lee; Song Cheol Kim; Jae Hoon Lee; Ki Byung Song; Ji Woong Hwang; Jeong Woo Lee; Dong Joo Lee; Kwang Min Park Journal: World J Surg Date: 2014-12 Impact factor: 3.352
Authors: Danielle M Hari; J Harrison Howard; Anna M Leung; Connie G Chui; Myung-Shin Sim; Anton J Bilchik Journal: HPB (Oxford) Date: 2012-09-26 Impact factor: 3.647