BACKGROUND: The aim of this retrospective study was to review all patients diagnosed with gallbladder cancer over a 10-year period to assess variables affecting survival. METHODS: Patients diagnosed with gallbladder cancer from January 1990 to December 1999 were identified from the Lothian Surgical Audit database and a case-note review was performed. RESULTS: The 44 patients who were studied (33 women, 11 men) had a mean age of 66 years (range 42-90 years). The diagnosis was established preoperatively in 25 patients (57%), intraoperatively in 5 patients (11%) and incidentally following pathological examination of cholecystectomy specimens in 14 patients (32%). None of the 25 patients diagnosed preoperatively underwent curative operations (median survival 4 months). All five patients diagnosed at the time of attempted cholecystectomy had advanced irresectable disease (median survival 1 month). The overall median survival in 14 patients with an incidental diagnosis of gallbladder cancer was 16 months; however, in eight of these patients who were considered to have had a potentially curative resection, the median survival was 38 months. DISCUSSION: The prognosis for patients diagnosed preoperatively or at the time of cholecystectomy is very poor. Patients with an incidental finding of gallbladder cancer have a significantly better prognosis and should be considered for further radical re-resection.
BACKGROUND: The aim of this retrospective study was to review all patients diagnosed with gallbladder cancer over a 10-year period to assess variables affecting survival. METHODS:Patients diagnosed with gallbladder cancer from January 1990 to December 1999 were identified from the Lothian Surgical Audit database and a case-note review was performed. RESULTS: The 44 patients who were studied (33 women, 11 men) had a mean age of 66 years (range 42-90 years). The diagnosis was established preoperatively in 25 patients (57%), intraoperatively in 5 patients (11%) and incidentally following pathological examination of cholecystectomy specimens in 14 patients (32%). None of the 25 patients diagnosed preoperatively underwent curative operations (median survival 4 months). All five patients diagnosed at the time of attempted cholecystectomy had advanced irresectable disease (median survival 1 month). The overall median survival in 14 patients with an incidental diagnosis of gallbladder cancer was 16 months; however, in eight of these patients who were considered to have had a potentially curative resection, the median survival was 38 months. DISCUSSION: The prognosis for patients diagnosed preoperatively or at the time of cholecystectomy is very poor. Patients with an incidental finding of gallbladder cancer have a significantly better prognosis and should be considered for further radical re-resection.
Authors: K Tsukada; I Kurosaki; K Uchida; Y Shirai; Y Oohashi; N Yokoyama; H Watanabe; K Hatakeyama Journal: Cancer Date: 1997-08-15 Impact factor: 6.860
Authors: Javier C Lendoire; Luis Gil; Fernando Duek; Carlos Quarin; Verónica Garay; Gabriel Raffin; Marcelo Rivaldi; Oks Alejandra; Oscar Imventarza Journal: HPB (Oxford) Date: 2012-06-08 Impact factor: 3.647
Authors: Fabio Ausania; Theodoris Tsirlis; Steven A White; Jeremy J French; Bryon C Jaques; Richard M Charnley; Derek M Manas Journal: HPB (Oxford) Date: 2013-01-07 Impact factor: 3.647
Authors: Kwondo Kim; DongAhn Yoo; Hee Seung Lee; Kyong Joo Lee; Soo Been Park; Chanyang Kim; Jung Hyun Jo; Dawoon E Jung; Si Young Song Journal: BMC Med Genomics Date: 2019-05-16 Impact factor: 3.063