Literature DB >> 9228952

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.

S F Bellon1, K K Rodgers, D G Schatz, J E Coleman, T A Steitz.   

Abstract

The crystal structure of the dimerization domain of the V(D)J recombination-activating protein, RAG1, was solved using zinc anomalous scattering. The structure reveals an unusual combination of multi-class zinc-binding motifs, including a zinc RING finger and a C2H2 zinc finger, that together from a single structural domain. The domain also contains a unique zinc binuclear cluster in place of a normally mononuclear zinc site in the RING finger. Together, four zinc ions help organize the entire domain, including the two helices that form the dimer interface.

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Year:  1997        PMID： 9228952     DOI： 10.1038/nsb0797-586

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  41 in total

1.  The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.

Authors:  V Aidinis; T Bonaldi; M Beltrame; S Santagata; M E Bianchi; E Spanopoulou
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Treble clef finger--a functionally diverse zinc-binding structural motif.

Authors:  N V Grishin
Journal:  Nucleic Acids Res       Date:  2001-04-15       Impact factor: 16.971

Review 3.  The RAG proteins in V(D)J recombination: more than just a nuclease.

Authors:  M J Sadofsky
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

Review 4.  RAG1 and RAG2 in V(D)J recombination and transposition.

Authors:  S D Fugmann
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

5.  Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex.

Authors:  Thomas K Albert; Hiroyuki Hanzawa; Yvonne I A Legtenberg; Marjolein J de Ruwe; Fiona A J van den Heuvel; Martine A Collart; Rolf Boelens; H Th Marc Timmers
Journal:  EMBO J       Date:  2002-02-01       Impact factor: 11.598

6.  Structural insights into the U-box, a domain associated with multi-ubiquitination.

Authors:  Melanie D Ohi; Craig W Vander Kooi; Joshua A Rosenberg; Walter J Chazin; Kathleen L Gould
Journal:  Nat Struct Biol       Date:  2003-04

7.  Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.

Authors:  LeAnn J Godderz; Negar S Rahman; George M Risinger; Janeen L Arbuckle; Karla K Rodgers
Journal:  Nucleic Acids Res       Date:  2003-04-01       Impact factor: 16.971

8.  BRIZ1 and BRIZ2 proteins form a heteromeric E3 ligase complex required for seed germination and post-germination growth in Arabidopsis thaliana.

Authors:  Mon Mandy Hsia; Judy Callis
Journal:  J Biol Chem       Date:  2010-09-01       Impact factor: 5.157

9.  The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases.

Authors:  Craig W Vander Kooi; Melanie D Ohi; Joshua A Rosenberg; Michael L Oldham; Marcia E Newcomer; Kathleen L Gould; Walter J Chazin
Journal:  Biochemistry       Date:  2006-01-10       Impact factor: 3.162

10.  Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Authors:  Rebecca Feltham; Maryline Moulin; James E Vince; Peter D Mace; Wendy Wei-Lynn Wong; Holly Anderton; Catherine L Day; David L Vaux; John Silke
Journal:  J Biol Chem       Date:  2010-03-30       Impact factor: 5.157
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