Literature DB >> 9226276

Dual multimodular class A penicillin-binding proteins in Mycobacterium leprae.

S Lepage1, P Dubois, T K Ghosh, B Joris, S Mahapatra, M Kundu, J Basu, P Chakrabarti, S T Cole, M Nguyen-Distèche, J M Ghuysen.   

Abstract

The ponA gene of cosmid L222 of the Mycobacterium leprae genome library encodes a multimodular class A penicillin-binding protein (PBP), PBP1. The PBP, labelled with a polyhistidine sequence, has been produced in Escherichia coli, extracted from the membranes with 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane-sulfonate (CHAPS) and purified by Ni2(+)-nitrilotriacetic acid-agarose chromatography. In contrast to the pon1-encoded class A PBP1, PBP1 undergoes denaturation at temperatures higher than 25 degrees C, it catalyzes acyl transfer reactions on properly structured thiolesters, and it binds penicillin with high affinity.

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Year:  1997        PMID： 9226276      PMCID： PMC179302          DOI： 10.1128/jb.179.14.4627-4630.1997

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  12 in total

1.  Monofunctional biosynthetic peptidoglycan transglycosylases.

Authors:  B G Spratt; J Zhou; M Taylor; M J Merrick
Journal:  Mol Microbiol       Date:  1996-02       Impact factor: 3.501

Review 2.  Penicillin and beyond: evolution, protein fold, multimodular polypeptides, and multiprotein complexes.

Authors:  J M Ghuysen; P Charlier; J Coyette; C Duez; E Fonzé; C Fraipont; C Goffin; B Joris; M Nguyen-Distèche
Journal:  Microb Drug Resist       Date:  1996       Impact factor: 3.431

3.  Identification and overexpression in Escherichia coli of a Mycobacterium leprae gene, pon1, encoding a high-molecular-mass class A penicillin-binding protein, PBP1.

Authors:  J Basu; S Mahapatra; M Kundu; S Mukhopadhyay; M Nguyen-Distèche; P Dubois; B Joris; J Van Beeumen; S T Cole; P Chakrabarti; J M Ghuysen
Journal:  J Bacteriol       Date:  1996-03       Impact factor: 3.490

4.  Streptomyces K15 active-site serine DD-transpeptidase: specificity profile for peptide, thiol ester and ester carbonyl donors and pathways of the transfer reactions.

Authors:  J Grandchamps; M Nguyen-Distèche; C Damblon; J M Frère; J M Ghuysen
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

5.  Amino acid sequence of the penicillin-binding protein/DD-peptidase of Streptomyces K15. Predicted secondary structures of the low Mr penicillin-binding proteins of class A.

Authors:  P Palomeque-Messia; S Englebert; M Leyh-Bouille; M Nguyen-Distèche; C Duez; S Houba; O Dideberg; J Van Beeumen; J M Ghuysen
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

6.  A novel glycan polymerase that synthesizes uncross-linked peptidoglycan in Escherichia coli.

Authors:  H Hara; H Suzuki
Journal:  FEBS Lett       Date:  1984-03-12       Impact factor: 4.124

7.  Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.

Authors:  M Jamin; C Damblon; S Millier; R Hakenbeck; J M Frère
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

8.  Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis?

Authors:  H F Chambers; D Moreau; D Yajko; C Miick; C Wagner; C Hackbarth; S Kocagöz; E Rosenberg; W K Hadley; H Nikaido
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

9.  Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae.

Authors:  K Eiglmeier; N Honoré; S A Woods; B Caudron; S T Cole
Journal:  Mol Microbiol       Date:  1993-01       Impact factor: 3.501

10.  Streptomyces K15 DD-peptidase-catalysed reactions with ester and amide carbonyl donors.

Authors:  M Nguyen-Distèche; M Leyh-Bouille; S Pirlot; J M Frère; J M Ghuysen
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857
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  9 in total

Review 1.  Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent.

Authors:  Colette Goffin; Jean-Marie Ghuysen
Journal:  Microbiol Mol Biol Rev       Date:  2002-12       Impact factor: 11.056

2.  The ponA gene of Enterococcus faecalis JH2-2 codes for a low-affinity class A penicillin-binding protein.

Authors:  Colette Duez; Séverine Hallut; Noureddine Rhazi; Séverine Hubert; Ana Amoroso; Fabrice Bouillenne; André Piette; Jacques Coyette
Journal:  J Bacteriol       Date:  2004-07       Impact factor: 3.490

3.  Overexpression, purification and biochemical characterization of a class A high-molecular-mass penicillin-binding protein (PBP), PBP1* and its soluble derivative from Mycobacterium tuberculosis.

Authors:  Sanjib Bhakta; Joyoti Basu
Journal:  Biochem J       Date:  2002-02-01       Impact factor: 3.857

Review 4.  Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs.

Authors:  C Goffin; J M Ghuysen
Journal:  Microbiol Mol Biol Rev       Date:  1998-12       Impact factor: 11.056

5.  Characterization of a Mycobacterium smegmatis mutant lacking penicillin binding protein 1.

Authors:  H Billman-Jacobe; R E Haites; R L Coppel
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

6.  N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatment.

Authors:  Sebabrata Mahapatra; Hataichanok Scherman; Patrick J Brennan; Dean C Crick
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

7.  Characterization of derivatives of the high-molecular-mass penicillin-binding protein (PBP) 1 of Mycobacterium leprae.

Authors:  S Mahapatra; S Bhakta; J Ahamed; J Basu
Journal:  Biochem J       Date:  2000-08-15       Impact factor: 3.857

8.  Identification, purification, and characterization of transpeptidase and glycosyltransferase domains of Streptococcus pneumoniae penicillin-binding protein 1a.

Authors:  A M Di Guilmi; N Mouz; J P Andrieu; J Hoskins; S R Jaskunas; J Gagnon; O Dideberg; T Vernet
Journal:  J Bacteriol       Date:  1998-11       Impact factor: 3.490

Review 9.  Bacterial growth and cell division: a mycobacterial perspective.

Authors:  Erik C Hett; Eric J Rubin
Journal:  Microbiol Mol Biol Rev       Date:  2008-03       Impact factor: 11.056
  9 in total

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