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Literature DB >> 9223513

Specific infection and destruction of dopaminergic neurons in the substantia nigra by Theiler's virus.

Abstract

Theiler's murine encephalomyelitis virus was stereotaxically inoculated unilaterally into the substantia nigra of the mouse brain. Virus specifically infected tyrosine hydroxylase-positive neurons and spread rostrocaudally throughout this subpopulation of neurons, resulting in impaired function and degeneration of the substantia nigra. The spread of the virus to other areas of the brain was minimal and rare.

Entities: Disease Species

Mesh：

Substances：

Year: 1997 PMID： 9223513 PMCID： PMC191879

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

24 in total

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7 in total

1. Prolonged gray matter disease without demyelination caused by Theiler's murine encephalomyelitis virus with a mutation in VP2 puff B.

Authors: I Tsunoda; Y Wada; J E Libbey; T S Cannon; F G Whitby; R S Fujinami
Journal: J Virol Date: 2001-08 Impact factor: 5.103

2. Alteration of the leptin network in late morbid obesity induced in mice by brain infection with canine distemper virus.

Authors: A Bernard; R Cohen; S T Khuth; B Vedrine; O Verlaeten; H Akaoka; P Giraudon; M F Belin
Journal: J Virol Date: 1999-09 Impact factor: 5.103