| Literature DB >> 9217966 |
T Ishikawa1, Z S Li, Y P Lu, P A Rea.
Abstract
This review addresses the recent molecular identification of several members of the glutathione S-conjugate (GS-X) pump family, a new class of ATP-binding cassette (ABC) transporters responsible for the elimination and/or sequestration of pharmacologically and agronomically important compounds in mammalian, yeast and plant cells. The molecular structure and function of GS-X pumps encoded by MRP, cMOAT, YCF1, and AtMRP genes, have been conserved throughout molecular evolution. The physiologic function of GS-X pumps is closely related with cellular detoxification, oxidative stress, inflammation, and cancer drug resistance. Coordinated expression of GS-X pump genes, e.g., MRP1 and YCF1, and gamma-glutamylcystaine synthetase, a rate-limiting enzyme of cellular glutathione (GSH) biosynthesis, has been frequently observed.Entities:
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Year: 1997 PMID： 9217966 DOI： 10.1023/a:1027385513483
Source DB: PubMed Journal: Biosci Rep ISSN： 0144-8463 Impact factor: 3.840