Literature DB >> 9212486

The effects and uses of heparin in the care of burns that improves treatment and enhances the quality of life.

M J Saliba.   

Abstract

Burn care has been mostly surgical, difficult, and expensive. The use of adequately large doses of heparin administered both parenterally and topically improved burn treatment and quality of life (1-20). Burn pain was relieved. Patients were not toxic. Tissue swelling, resuscitation fluids, and healing time were reduced. Pulmonary and intestinal pathology were notably absent. The new skin was smooth, comfortable, and contracture free. More than anticoagulating effect were seen. Antiinflammatory effects, active at acidic phs but not at alkaline phs, stopped burn pain inflammation, and extension. Neoangiogenic effects revascularized ischemic tissue. Reepithelializing effects were evident. Nonburn and recent burn studies confirmed that heparin had these strong properties and effects (7-13, 21-34). Medical and surgical procedures were reduced. Burn care became simpler and easier. Precautions to prevent bleeding were used. Current use of heparin is limited. Wider use is warranted.

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Year:  1997        PMID: 9212486

Source DB:  PubMed          Journal:  Acta Chir Plast        ISSN: 0001-5423


  9 in total

1.  Low molecular weight heparin-induced pharmacological modulation of burn wound healing.

Authors:  T Ravikumar; N Shanmugasundaram; V Jayaraman; K M Ramakrishnan; M Babu
Journal:  Ann Burns Fire Disasters       Date:  2006-09-30

2.  Pulmonary coagulopathy: a potential therapeutic target in different forms of lung injury.

Authors:  Marcus J Schultz; Marcel Levi
Journal:  Thorax       Date:  2007-07       Impact factor: 9.139

3.  5-year Angiographic and Clinical Follow-up of Coil-embolised Intradural Saccular Aneurysms. A Single Center Experience.

Authors:  L L Batista; J Mahadevan; M Sachet; H Alvarez; G Rodesch; P Lasjaunias
Journal:  Interv Neuroradiol       Date:  2004-10-20       Impact factor: 1.610

4.  A comparative study of paediatric thermal burns treated with topical heparin and without heparin.

Authors:  T S Venkatachalapathy
Journal:  Indian J Surg       Date:  2012-10-05       Impact factor: 0.656

Review 5.  Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhage.

Authors:  J Marc Simard; David Schreibman; E Francois Aldrich; Bernadette Stallmeyer; Brian Le; Robert F James; Narlin Beaty
Journal:  Neurocrit Care       Date:  2010-12       Impact factor: 3.210

6.  Heparin reduced mortality and sepsis in severely burned children.

Authors:  G J Zayas; A M Bonilla; M J Saliba
Journal:  Ann Burns Fire Disasters       Date:  2007-03-31

7.  A comparative study of burns treated with topical heparin and without heparin.

Authors:  T S Venakatachalapathy; S Mohan Kumar; M J Saliba
Journal:  Ann Burns Fire Disasters       Date:  2007-12-31

8.  Management of severe burn injuries with topical heparin: the first evidence-based study in Ghana.

Authors:  Pius Agbenorku; Setri Fugar; Joseph Akpaloo; Paa E Hoyte-Williams; Zainab Alhassan; Fareeda Agyei
Journal:  Int J Burns Trauma       Date:  2013-01-24

9.  Does low molecular weight heparin impair anastomotic wound healing?

Authors:  Emre Ergul; Yigit Mehmet Ozgun; Gulten Kiyak; Gonca Barit Ozgun; Birol Korukluoglu; Ahmet Kusdemir
Journal:  J Gastrointest Surg       Date:  2008-12-13       Impact factor: 3.452

  9 in total

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