| Literature DB >> 9211970 |
Abstract
We have sequenced and analyzed 8.3 kb of sequence adjacent and distal to the human ribosomal DNA (rDNA); this distal sequence connects to the rDNA cluster just 4 kb upstream of the first promoter and is shared among the acrocentric chromosomes and, at least in part, it is also present in other primates. The sequence differs in character from that of the rDNA intergenic spacer (IGS) in that it does not contain long stretches of either polypyrimidine or polypurine. However, just like the IGS, it contains numerous repetitive elements, including retroposed fragments of 28S rRNA and large pieces of the IGS. In addition, we show that the rDNA clusters are not interrupted by other sequences and do not recombine with this distal segment.Entities:
Mesh:
Substances:
Year: 1997 PMID: 9211970 DOI: 10.1007/bf02510479
Source DB: PubMed Journal: Chromosoma ISSN: 0009-5915 Impact factor: 4.316