INTRODUCTION: Abnormalities of ventricular repolarization leading to ventricular arrhythmias place children with long QT syndrome at high risk for sudden death. Dispersion of the QT (QTd) and JT (JTd) intervals, as markers of cardiac electrical heterogeneity, may be helpful in evaluating children with long QT syndrome and identifying a subset of patients at high risk for development of critical ventricular arrhythmias (ventricular tachycardia, torsades de pointes, and/or cardiac arrest). METHODS AND RESULTS: The QTd and JTd intervals in 39 children with long QT syndrome were compared to those of 50 normal age-matched children. In the long QT syndrome group, QTd measured 81 +/- 70 msec compared to 28 +/- 14 msec in the control group (P < 0.05), and JTd in the long QT syndrome group was 80 +/- 69 msec compared to 25 +/- 15 msec in the control group (P < 0.05). CONCLUSION: Children with long QT syndrome have an increased QTd and JTd when compared to normal controls. A QTd or JTd > or = 55 msec correlates with the presence of critical ventricular arrhythmias. These ECG measures of dispersion can be useful in stratifying children with the long QT syndrome who are at higher risk for developing critical ventricular arrhythmias.
INTRODUCTION: Abnormalities of ventricular repolarization leading to ventricular arrhythmias place children with long QT syndrome at high risk for sudden death. Dispersion of the QT (QTd) and JT (JTd) intervals, as markers of cardiac electrical heterogeneity, may be helpful in evaluating children with long QT syndrome and identifying a subset of patients at high risk for development of critical ventricular arrhythmias (ventricular tachycardia, torsades de pointes, and/or cardiac arrest). METHODS AND RESULTS: The QTd and JTd intervals in 39 children with long QT syndrome were compared to those of 50 normal age-matched children. In the long QT syndrome group, QTd measured 81 +/- 70 msec compared to 28 +/- 14 msec in the control group (P < 0.05), and JTd in the long QT syndrome group was 80 +/- 69 msec compared to 25 +/- 15 msec in the control group (P < 0.05). CONCLUSION:Children with long QT syndrome have an increased QTd and JTd when compared to normal controls. A QTd or JTd > or = 55 msec correlates with the presence of critical ventricular arrhythmias. These ECG measures of dispersion can be useful in stratifying children with the long QT syndrome who are at higher risk for developing critical ventricular arrhythmias.
Authors: Vassilios P Vassilikos; Labros A Karagounis; Apostolos Psichogios; Themistoclis Maounis; John Iakovou; Antonis S Manolis; Dennis V Cokkinos Journal: Ann Noninvasive Electrocardiol Date: 2002-01 Impact factor: 1.468
Authors: Udi Nussinovitch; Naomi Nussinovitch; Moshe Nussinovitch; Benjamin Volovitz; Olga Feld; Ilan Ben-Zvi; Avi Livneh Journal: Rheumatol Int Date: 2011-04-02 Impact factor: 2.631
Authors: Hamid Amoozgar; Ahmad Ali Amirghofran; Shirvan Salaminia; Sirous Cheriki; Mohammad Borzoee; Gholamhossein Ajami; Farah Peiravian Journal: Int Cardiovasc Res J Date: 2014-09-01