| Literature DB >> 9207912 |
A Shafiee1, H Motamedi, F J Dumont, B H Arison, R R Miller.
Abstract
Two genetically engineered mutant strains of Streptomyces sp. MA6548 produced two FK506 analogs, 9-deoxo-31-O-demethylFK506 and 31-O-demethylFK506. The structures were determined by a combination of NMR and mass spectrometry. These compounds exhibited immunosuppressive and antifungal activities, albeit reduced, compared to FK506. Both compounds contain a free hydroxyl group at C-31 for the synthesis of novel FK506 derivatives.Entities:
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Year: 1997 PMID： 9207912 DOI： 10.7164/antibiotics.50.418
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649