Literature DB >> 26342319

The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects.

Yeon Hee Ban1, Sung Ryeol Park2, Yeo Joon Yoon3.   

Abstract

FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.

Entities:  

Keywords:  Biological activity; Biosynthetic pathway; FK506; FK506 analogs; Genetic engineering; Production improvement

Mesh：

Substances：

Year:  2015        PMID： 26342319     DOI： 10.1007/s10295-015-1677-7

Source DB:  PubMed          Journal:  J Ind Microbiol Biotechnol        ISSN： 1367-5435            Impact factor:   3.346


  57 in total

1.  Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.

Authors:  SangJoon Mo; Young Ji Yoo; Yeon Hee Ban; Sung-Kwon Lee; Eunji Kim; Joo-Won Suh; Yeo Joon Yoon
Journal:  Appl Environ Microbiol       Date:  2012-01-20       Impact factor: 4.792

2.  FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

Authors:  T Kino; H Hatanaka; S Miyata; N Inamura; M Nishiyama; T Yajima; T Goto; M Okuhara; M Kohsaka; H Aoki
Journal:  J Antibiot (Tokyo)       Date:  1987-09       Impact factor: 2.649

3.  FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Authors:  T Kino; H Hatanaka; M Hashimoto; M Nishiyama; T Goto; M Okuhara; M Kohsaka; H Aoki; H Imanaka
Journal:  J Antibiot (Tokyo)       Date:  1987-09       Impact factor: 2.649

4.  Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011.

Authors:  SangJoon Mo; Sung-Kwon Lee; Ying-Yu Jin; Chung-Hun Oh; Joo-Won Suh
Journal:  Appl Microbiol Biotechnol       Date:  2012-10-02       Impact factor: 4.813

5.  Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin).

Authors:  K P High; R G Washburn
Journal:  J Infect Dis       Date:  1997-01       Impact factor: 5.226

6.  Origin of the allyl group in FK506 biosynthesis.

Authors:  Dusan Goranovic; Gregor Kosec; Peter Mrak; Stefan Fujs; Jaka Horvat; Enej Kuscer; Gregor Kopitar; Hrvoje Petkovic
Journal:  J Biol Chem       Date:  2010-03-01       Impact factor: 5.157

7.  The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

Authors:  K Wu; L Chung; W P Revill; L Katz; C D Reeves
Journal:  Gene       Date:  2000-06-13       Impact factor: 3.688

Review 8.  Cyclosporin A. Clinical pharmacology and therapeutic potential.

Authors:  D J White
Journal:  Drugs       Date:  1982-10       Impact factor: 9.546

9.  Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.

Authors:  Dandan Chen; Qi Zhang; Qinglin Zhang; Peilin Cen; Zhinan Xu; Wen Liu
Journal:  Appl Environ Microbiol       Date:  2012-05-11       Impact factor: 4.792

10.  Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement.

Authors:  Di Huang; Shanshan Li; Menglei Xia; Jianping Wen; Xiaoqiang Jia
Journal:  Microb Cell Fact       Date:  2013-05-24       Impact factor: 5.328
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  10 in total

1.  Bluemomycin, a new naphthoquinone derivative from Streptomyces sp. with antimicrobial and cytotoxic properties.

Authors:  C Balachandran; N A Al-Dhabi; V Duraipandiyan; S Ignacimuthu
Journal:  Biotechnol Lett       Date:  2021-01-29       Impact factor: 2.461

2.  In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.

Authors:  Yeonseon Lee; Kyung-Tae Lee; Soo Jung Lee; Ji Yoon Beom; Areum Hwangbo; Jin A Jung; Myoung Chong Song; Young Ji Yoo; Sang Hyeon Kang; Anna F Averette; Joseph Heitman; Yeo Joon Yoon; Eunji Cheong; Yong-Sun Bahn
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

3.  Protective Effects of Nargenicin A1 against Tacrolimus-Induced Oxidative Stress in Hirame Natural Embryo Cells.

Authors:  Cheol Park; Da Hye Kwon; Su Jung Hwang; Min Ho Han; Jin-Woo Jeong; Sang Hoon Hong; Hee-Jae Cha; Su-Hyun Hong; Gi-Young Kim; Hyo-Jong Lee; Suhkmann Kim; Heui-Soo Kim; Yung Hyun Choi
Journal:  Int J Environ Res Public Health       Date:  2019-03-22       Impact factor: 3.390

4.  Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.

Authors:  Praveen R Juvvadi; David Fox; Benjamin G Bobay; Michael J Hoy; Sophie M C Gobeil; Ronald A Venters; Zanetta Chang; Jackie J Lin; Anna Floyd Averette; D Christopher Cole; Blake C Barrington; Joshua D Wheaton; Maria Ciofani; Michael Trzoss; Xiaoming Li; Soo Chan Lee; Ying-Lien Chen; Mitchell Mutz; Leonard D Spicer; Maria A Schumacher; Joseph Heitman; William J Steinbach
Journal:  Nat Commun       Date:  2019-09-19       Impact factor: 14.919

5.  Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis.

Authors:  Qing-Bin Wu; Xiao-Ying Zhang; Xin-Ai Chen; Yong-Quan Li
Journal:  Microb Cell Fact       Date:  2021-08-23       Impact factor: 5.328

6.  Streptomyces tsukubensis VKM Aс-2618D-an Effective Producer of Tacrolimus.

Authors:  V Yu Poshekhontseva; V V Fokina; S V Tarlachkov; A V Machulin; A A Shutov; M V Donova
Journal:  Appl Biochem Microbiol       Date:  2021-12-14       Impact factor: 0.886

Review 7.  Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.

Authors:  María Ordóñez-Robles; Fernando Santos-Beneit; Juan F Martín
Journal:  Antibiotics (Basel)       Date:  2018-05-01

8.  Evaluation of carbon:nitrogen ratio in semi-defined culture medium to tacrolimus biosynthesis by Streptomyces tsukubaensis and the effect on bacterial growth.

Authors:  Jean Vinícius Moreira; Seforah Carolina Marques Silva; Marco Aurélio Cremasco
Journal:  Biotechnol Rep (Amst)       Date:  2020-02-20

Review 9.  Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens.

Authors:  Sandeep Vellanki; Alexis E Garcia; Soo Chan Lee
Journal:  Front Mol Biosci       Date:  2020-10-16

Review 10.  Genome mining for drug discovery: progress at the front end.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258
  10 in total

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