Literature DB >> 9207145

A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter.

C Sur1, H Betz, P Schloss.   

Abstract

The serotonin transporter (SERT) is a member of the Na+/Cl--dependent neurotransmitter transporter family and constitutes the target of several clinically important antidepressants. Here, replacement of serine-545 in the recombinant rat SERT by alanine was found to alter the cation dependence of serotonin uptake. Substrate transport was now driven as efficiently by LiCl as by NaCl without significant changes in serotonin affinity. Binding of the antidepressant [3H]imipramine occurred with 1/5th the affinity, whereas [3H]citalopram binding was unchanged. These results indicate that serine-545 is a crucial determinant of both the cation dependence of serotonin transport by SERT and the imipramine binding properties of SERT.

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Year:  1997        PMID： 9207145      PMCID： PMC23875          DOI： 10.1073/pnas.94.14.7639

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Isolation of cDNAs encoding a novel member of the neurotransmitter transporter gene family.

Authors:  W Mayser; H Betz; P Schloss
Journal:  FEBS Lett       Date:  1991-12-16       Impact factor: 4.124

2.  Cloning of a serotonin transporter affected by antidepressants.

Authors:  B J Hoffman; E Mezey; M J Brownstein
Journal:  Science       Date:  1991-10-25       Impact factor: 47.728

3.  The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues.

Authors:  P Schloss; W Mayser; H Betz
Journal:  Biochem Biophys Res Commun       Date:  1994-01-28       Impact factor: 3.575

Review 4.  Sodium ion-dependent transporters for neurotransmitters: a review of recent developments.

Authors:  D M Worrall; D C Williams
Journal:  Biochem J       Date:  1994-02-01       Impact factor: 3.857

Review 5.  Neurotransmitter transporters: three distinct gene families.

Authors:  S G Amara; J L Arriza
Journal:  Curr Opin Neurobiol       Date:  1993-06       Impact factor: 6.627

6.  Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

Authors:  S Ramamoorthy; A L Bauman; K R Moore; H Han; T Yang-Feng; A S Chang; V Ganapathy; R D Blakely
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

7.  A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization.

Authors:  J L Corey; M W Quick; N Davidson; H A Lester; J Guastella
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

8.  Importance of Arg-219 for correct biogenesis of alpha 1 homooligomeric glycine receptors.

Authors:  D Langosch; A Herbold; V Schmieden; J Borman; J Kirsch
Journal:  FEBS Lett       Date:  1993-12-28       Impact factor: 4.124

9.  Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

Authors:  S Kitayama; S Shimada; H Xu; L Markham; D M Donovan; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

10.  Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers.

Authors:  J Bormann; N Rundström; H Betz; D Langosch
Journal:  EMBO J       Date:  1993-10       Impact factor: 11.598
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  8 in total

Review 1.  Recognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transporters.

Authors:  Christopher K Surratt; Okechukwu T Ukairo; Suneetha Ramanujapuram
Journal:  AAPS J       Date:  2005-10-27       Impact factor: 4.009

2.  Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter.

Authors:  Naomi Oshiro; Ana M Pajor
Journal:  Biochim Biophys Acta       Date:  2006-05-16

3.  The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.

Authors:  Jacob P R Jacobsen; Per Plenge; Benjamin D Sachs; Alan L Pehrson; Manuel Cajina; Yunzhi Du; Wendy Roberts; Meghan L Rudder; Prachiti Dalvi; Taylor J Robinson; Sharon P O'Neill; King S Khoo; Connie Sanchez Morillo; Xiaodong Zhang; Marc G Caron
Journal:  Psychopharmacology (Berl)       Date:  2014-05-09       Impact factor: 4.530

4.  Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Authors:  Jacob Andersen; Olivier Taboureau; Kasper B Hansen; Lars Olsen; Jan Egebjerg; Kristian Strømgaard; Anders S Kristensen
Journal:  J Biol Chem       Date:  2009-02-12       Impact factor: 5.157

5.  Molecular model of the neural dopamine transporter.

Authors:  Aina Westrheim Ravna; Ingebrigt Sylte; Svein G Dahl
Journal:  J Comput Aided Mol Des       Date:  2003 May-Jun       Impact factor: 3.686

6.  Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters.

Authors:  Y Cao; M Li; S Mager; H A Lester
Journal:  J Neurosci       Date:  1998-10-01       Impact factor: 6.167

7.  Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes.

Authors:  M Horiuchi; A Nicke; J Gomeza; A Aschrafi; G Schmalzing; H Betz
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-06       Impact factor: 11.205

8.  N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism.

Authors:  Keiko Iwata; Hideo Matsuzaki; Taro Tachibana; Koji Ohno; Saori Yoshimura; Hironori Takamura; Kohei Yamada; Shinsuke Matsuzaki; Kazuhiko Nakamura; Kenji J Tsuchiya; Kaori Matsumoto; Masatsugu Tsujii; Toshirou Sugiyama; Taiichi Katayama; Norio Mori
Journal:  Mol Autism       Date:  2014-05-10       Impact factor: 7.509
  8 in total

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