Literature DB >> 1948036

Cloning of a serotonin transporter affected by antidepressants.

B J Hoffman1, E Mezey, M J Brownstein.   

Abstract

A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine.

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Year:  1991        PMID： 1948036     DOI： 10.1126/science.1948036

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  112 in total

1.  A role for the serotonin transporter in hypoxia-induced pulmonary hypertension.

Authors:  B L Fanburg; S L Lee
Journal:  J Clin Invest       Date:  2000-06       Impact factor: 14.808

2.  The state of the serotonin transporter protein in the platelets of patients with somatoform [correction of somatiform] disorders.

Authors:  A R Belous; S Ramamoorthy; R D Blakely; M I Factor; A M Dupin; A B Katasonov; R H Lozier; A G Beniashvili; M A Morozova; O S Brusov
Journal:  Neurosci Behav Physiol       Date:  2001 Mar-Apr

Review 3.  High-affinity choline transporter.

Authors:  Takashi Okuda; Tatsuya Haga
Journal:  Neurochem Res       Date:  2003-04       Impact factor: 3.996

4.  Enhancement of serotonin uptake by cortisol: a possible link between stress and depression.

Authors:  G E Tafet; M Toister-Achituv; M Shinitzky
Journal:  Cogn Affect Behav Neurosci       Date:  2001-03       Impact factor: 3.282

5.  Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression.

Authors:  G E Tafet; V P Idoyaga-Vargas; D P Abulafia; J M Calandria; S S Roffman; A Chiovetta; M Shinitzky
Journal:  Cogn Affect Behav Neurosci       Date:  2001-12       Impact factor: 3.282

6.  Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.

Authors:  Q R Liu; B López-Corcuera; H Nelson; S Mandiyan; N Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

Review 7.  The solute carrier 6 family of transporters.

Authors:  Stefan Bröer; Ulrik Gether
Journal:  Br J Pharmacol       Date:  2012-09       Impact factor: 8.739

Review 8.  Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels.

Authors:  Charles P Mercado; Fusun Kilic
Journal:  Mol Interv       Date:  2010-08

9.  Cocaine binding sites in fetal rat brain: implications for prenatal cocaine action.

Authors:  J S Meyer; L P Shearman; L M Collins; R L Maguire
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

Authors:  S Ramamoorthy; A L Bauman; K R Moore; H Han; T Yang-Feng; A S Chang; V Ganapathy; R D Blakely
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205
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