Literature DB >> 9201254

Changes in N-acetylglucosaminyltransferase III, IV and V in renal cell carcinoma.

T Y Zhu1, H L Chen, J X Gu, Y F Zhang, Y K Zhang, R A Zhang.   

Abstract

The activities of N-acetylglucosaminyltransferase (GnT) III, IV and V were determined in 10 cases of renal cell carcinoma (RCC) and compared with the normal kidney cortex (NKC) regions of the same kidney resected from RCC patients. It was found that the GnT III and GnT IV activities decreased consistently in all samples of RCC, while GnT V activity increased, decreased or did not change in different samples. The mean levels of GnT III and GnT IV activities in RCC were found to be very significantly lower than those of NKC on statistical analysis, but the mean value of GnT V activity was almost identical in RCC and NKC. The decrease in GnT activities in RCC were compatible with the decrease in bisecting N-acetylglucosamine (GlcNAc) and antennary number of complex-type N-glycans in gamma-glutamyltranspeptidase (gamma-GT) partially purified from RCCs as studied with concanavalin A (ConA) affinity column chromatography, which showed a decrease of unbound fraction and increase of bound fractions.

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Year:  1997        PMID: 9201254     DOI: 10.1007/bf01208642

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN: 0171-5216            Impact factor:   4.553


  16 in total

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Authors:  H Nakao; A Nishikawa; T Karasuno; T Nishiura; M Iida; Y Kanayama; T Yonezawa; S Tarui; N Taniguchi
Journal:  Biochem Biophys Res Commun       Date:  1990-11-15       Impact factor: 3.575

Review 2.  Asn-linked oligosaccharide processing and malignant potential.

Authors:  J W Dennis
Journal:  Cancer Surv       Date:  1988

3.  A new fluorimetric method for the determination of gamma-glutamyltransferase activity in blood serum.

Authors:  E Prusak; M Siewiński; A Szewczuk
Journal:  Clin Chim Acta       Date:  1980-10-23       Impact factor: 3.786

4.  Regulation of N-acetylglucosaminyltransferase V by protein kinases.

Authors:  T Z Ju; H L Chen; J X Gu; H Qin
Journal:  Glycoconj J       Date:  1995-12       Impact factor: 2.916

5.  Reexamination of the pyridylamination used for fluorescence labeling of oligosaccharides and its application to glycoproteins.

Authors:  S Hase; T Ibuki; T Ikenaka
Journal:  J Biochem       Date:  1984-01       Impact factor: 3.387

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Authors:  K Yamamura; S Takasaki; M Ichihashi; Y Mishima; A Kobata
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7.  Structural changes induced in the sugar chains of glycoproteins by malignant transformation of producing cells and their clinical application.

Authors:  A Kobata
Journal:  Biochimie       Date:  1988-11       Impact factor: 4.079

8.  Specificity of concanavalin A binding to asparagine-linked glycopeptides. A nuclear magnetic relaxation dispersion study.

Authors:  C F Brewer; L Bhattacharyya
Journal:  J Biol Chem       Date:  1986-06-05       Impact factor: 5.157

9.  Structures of sugar chains of human kidney gamma-glutamyltranspeptidase.

Authors:  K Yamashita; A Hitoi; Y Matsuda; T Miura; N Katunuma; A Kobata
Journal:  J Biochem       Date:  1986-01       Impact factor: 3.387

10.  The biosynthesis of highly branched N-glycans: studies on the sequential pathway and functional role of N-acetylglucosaminyltransferases I, II, III, IV, V and VI.

Authors:  I Brockhausen; S Narasimhan; H Schachter
Journal:  Biochimie       Date:  1988-11       Impact factor: 4.079

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  6 in total

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2.  Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma.

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3.  Multidimensional liquid chromatography platform for profiling alterations of clusterin N-glycosylation in the plasma of patients with renal cell carcinoma.

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Review 4.  Glycosylation in Renal Cell Carcinoma: Mechanisms and Clinical Implications.

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5.  Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma.

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Journal:  Glycoconj J       Date:  2004       Impact factor: 3.009

6.  N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma.

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Journal:  Mol Cancer       Date:  2007-05-09       Impact factor: 27.401

  6 in total

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