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Literature DB >> 9195866

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds.

J A Gerlt¹, M M Kreevoy, W Cleland, P A Frey.

Abstract

We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

Entities: Chemical

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Year: 1997 PMID： 9195866 DOI： 10.1016/s1074-5521(97)90069-7

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

33 in total

1. Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.

Authors: Jason P Schwans; Daniel A Kraut; Daniel Herschlag
Journal: Proc Natl Acad Sci U S A Date: 2009-08-12 Impact factor: 11.205

2. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.

Authors: Vanessa Iiams; Bijoy J Desai; Alexander A Fedorov; Elena V Fedorov; Steven C Almo; John A Gerlt
Journal: Biochemistry Date: 2011-09-06 Impact factor: 3.162

3. Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein.

Authors: Aaron C Robinson; Carlos A Castañeda; Jamie L Schlessman; E Bertrand García-Moreno
Journal: Proc Natl Acad Sci U S A Date: 2014-07-29 Impact factor: 11.205

4. Consequences of breaking the Asp-His hydrogen bond of the catalytic triad: effects on the structure and dynamics of the serine esterase cutinase.

Authors: E Y Lau; T C Bruice
Journal: Biophys J Date: 1999-07 Impact factor: 4.033

5. Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.

Authors: A M Mulichak; M J Theisen; B Essigmann; C Benning; R M Garavito
Journal: Proc Natl Acad Sci U S A Date: 1999-11-09 Impact factor: 11.205

10. A "Seleno Effect" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase.

Authors: John P O'Keefe; Christopher M Dustin; Drew Barber; Gregg W Snider; Robert J Hondal
Journal: Biochemistry Date: 2018-03-06 Impact factor: 3.162

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds.

1. Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.

2. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.

3. Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein.

4. Consequences of breaking the Asp-His hydrogen bond of the catalytic triad: effects on the structure and dynamics of the serine esterase cutinase.

5. Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.

6. Catalytic role of enzymes: short strong H-bond-induced partial proton shuttles and charge redistributions.

7. Symmetry of three-center, four-electron bonds.

8. On the electronic nature of low-barrier hydrogen bonds in enzymatic reactions.

9. Mechanisms for Two-Step Proton Transfer Reactions in the Outward-Facing Form of MATE Transporter.

10. A "Seleno Effect" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase.