Literature DB >> 9188529

Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients.

M B Rettig1, H J Ma, R A Vescio, M Põld, G Schiller, D Belson, A Savage, C Nishikubo, C Wu, J Fraser, J W Said, J R Berenson.   

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.

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Year:  1997        PMID： 9188529     DOI： 10.1126/science.276.5320.1851

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  83 in total

1.  Lymphoid disorders associated with HHV-8/KSHV infection: facts and contentions.

Authors:  G Gaidano; E Castaños-Velez; P Biberfeld
Journal:  Med Oncol       Date:  1999-04       Impact factor: 3.064

2.  Epstein-Barr virus recombinants from BC-1 and BC-2 can immortalize human primary B lymphocytes with different levels of efficiency and in the absence of coinfection by Kaposi's sarcoma-associated herpesvirus.

Authors:  A J Aguirre; E S Robertson
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

Review 3.  Gammaherpesviruses and "Hit-and-Run" oncogenesis.

Authors:  R F Ambinder
Journal:  Am J Pathol       Date:  2000-01       Impact factor: 4.307

4.  Polymerase chain reaction detection of Kaposi's sarcoma-associated herpesvirus-optimized protocols and their application to myeloma.

Authors:  L Pan; L Milligan; J Michaeli; E Cesarman; D M Knowles
Journal:  J Mol Diagn       Date:  2001-02       Impact factor: 5.568

Review 5.  Recent advances in haematology.

Authors:  D Provan; D F O'Shaughnessy
Journal:  BMJ       Date:  1999-04-10

6.  High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations.

Authors:  J C Zong; D M Ciufo; D J Alcendor; X Wan; J Nicholas; P J Browning; P L Rady; S K Tyring; J M Orenstein; C S Rabkin; I J Su; K F Powell; M Croxson; K E Foreman; B J Nickoloff; S Alkan; G S Hayward
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

7.  Socioeconomic status and multiple myeloma among US blacks and whites.

Authors:  D Baris; L M Brown; D T Silverman; R Hayes; R N Hoover; G M Swanson; M Dosemeci; A G Schwartz; J M Liff; J B Schoenberg; L M Pottern; J Lubin; R S Greenberg; J F Fraumeni
Journal:  Am J Public Health       Date:  2000-08       Impact factor: 9.308

Review 8.  Multiple myeloma.

Authors:  N Raje; K C Anderson
Journal:  Curr Treat Options Oncol       Date:  2000-04

9.  Absence of HHV-8 DNA sequences in malignant mesothelioma.

Authors:  V Ascoli; F Nardi; C Carnovale Scalzo; S Signoretti; A Pistilli; F Lo Coco
Journal:  Mol Pathol       Date:  1998-04

10.  A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus.

Authors:  R Sun; S F Lin; L Gradoville; Y Yuan; F Zhu; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205
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