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Literature DB >> 9174205

Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila.

T M Suter¹, V K Viswanathan, N P Cianciotto.

Abstract

A gene capable of conferring spectinomycin resistance was isolated from Legionella pneumophila, the agent of Legionnaires' disease. The gene (aph) encoded a 36-kDa protein which has similarity to aminoglycoside phosphotransferases. Biochemical analysis confirmed that aph encodes a phosphotransferase which modifies spectinomycin but not hygromycin, kanamycin, or streptomycin. The strain that was the source of aph demonstrated resistance to spectinomycin, and Southern hybridizations determined that aph also exists in other legionellae.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1997 PMID： 9174205 PMCID： PMC163921 DOI： 10.1128/AAC.41.6.1385

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

26 in total

1. Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue.

Authors: P R Thompson; D W Hughes; G D Wright
Journal: Chem Biol Date: 1996-09

2. Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase.

Authors: S Hollingshead; D Vapnek
Journal: Plasmid Date: 1985-01 Impact factor: 3.466

3. Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3") (9).

Authors: E Murphy
Journal: Mol Gen Genet Date: 1985

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Authors: B G Moffie; R P Mouton
Journal: J Antimicrob Chemother Date: 1988-10 Impact factor: 5.790

Review 5. Legionnaires disease: historical perspective.

Authors: W C Winn
Journal: Clin Microbiol Rev Date: 1988-01 Impact factor: 26.132

6. Nucleotide sequence of the kanamycin resistance transposon Tn903.

Authors: A Oka; H Sugisaki; M Takanami
Journal: J Mol Biol Date: 1981-04-05 Impact factor: 5.469

7. Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing.

Authors: K R Kaster; S G Burgett; R N Rao; T D Ingolia
Journal: Nucleic Acids Res Date: 1983-10-11 Impact factor: 16.971

8. Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes.

Authors: P Martin; E Jullien; P Courvalin
Journal: Mol Microbiol Date: 1988-09 Impact factor: 3.501

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Authors: J N Dowling; D A McDevitt; A W Pasculle
Journal: Antimicrob Agents Chemother Date: 1985-02 Impact factor: 5.191

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Authors: T Fujii; K Sato; K Miyata; M Inoue; S Mitsuhashi
Journal: Antimicrob Agents Chemother Date: 1986-05 Impact factor: 5.191

11 in total

1. Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila.

Authors: Christopher T Lemke; Jiyoung Hwang; Bing Xiong; Nicholas P Cianciotto; Albert M Berghuis
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2005-06-01

2. Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Authors: David F Bruhn; Samanthi L Waidyarachchi; Dora B Madhura; Dimitri Shcherbakov; Zhong Zheng; Jiuyu Liu; Yasser M Abdelrahman; Aman P Singh; Stefan Duscha; Chetan Rathi; Robin B Lee; Robert J Belland; Bernd Meibohm; Jason W Rosch; Erik C Böttger; Richard E Lee
Journal: Sci Transl Med Date: 2015-05-20 Impact factor: 17.956

3. Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway.

Authors: Magnus Unemo; Daniel Golparian; Vegard Skogen; Anne Olaug Olsen; Harald Moi; Gaute Syversen; Stig Ove Hjelmevoll
Journal: Antimicrob Agents Chemother Date: 2012-11-26 Impact factor: 5.191

4. Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.

Authors: M Galimand; G Gerbaud; P Courvalin
Journal: Antimicrob Agents Chemother Date: 2000-05 Impact factor: 5.191

Review 5. Aminoglycoside modifying enzymes.

Authors: Maria S Ramirez; Marcelo E Tolmasky
Journal: Drug Resist Updat Date: 2010-09-15 Impact factor: 18.500