Literature DB >> 9171115

Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments.

C Barlow1, M Schroeder, J Lekstrom-Himes, H Kylefjord, C X Deng, A Wynshaw-Boris, B M Spiegelman, K G Xanthopoulos.   

Abstract

Functional analysis of mammalian genes relies, in part, on targeted mutations generated by homologous recombination in mice. We have developed a strategy for adipose-specific inactivation of loxP-floxed gene segments. Transgenic mice have been established that express Cre recombinase under the control of the adipose-specific aP2 enhancer/promoter. Crossing of the aP2/ Cre mice with any loxP-floxed gene will facilitate its functional analysis in adipose tissue.

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Year:  1997        PMID： 9171115      PMCID： PMC146759          DOI： 10.1093/nar/25.12.2543

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  14 in total

1.  Tissue- and site-specific DNA recombination in transgenic mice.

Authors:  P C Orban; D Chui; J D Marth
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

Review 2.  Altering the genome by homologous recombination.

Authors:  M R Capecchi
Journal:  Science       Date:  1989-06-16       Impact factor: 47.728

3.  A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.

Authors:  S R Ross; R A Graves; A Greenstein; K A Platt; H L Shyu; B Mellovitz; B M Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

4.  Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.

Authors:  B Sauer; N Henderson
Journal:  New Biol       Date:  1990-05

5.  Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

Authors:  B Sauer; N Henderson
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

6.  Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.

Authors:  H Gu; Y R Zou; K Rajewsky
Journal:  Cell       Date:  1993-06-18       Impact factor: 41.582

7.  Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites.

Authors:  N Sternberg; D Hamilton
Journal:  J Mol Biol       Date:  1981-08-25       Impact factor: 5.469

8.  Targeted oncogene activation by site-specific recombination in transgenic mice.

Authors:  M Lakso; B Sauer; B Mosinger; E J Lee; R W Manning; S H Yu; K L Mulder; H Westphal
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

9.  Subregion- and cell type-restricted gene knockout in mouse brain.

Authors:  J Z Tsien; D F Chen; D Gerber; C Tom; E H Mercer; D J Anderson; M Mayford; E R Kandel; S Tonegawa
Journal:  Cell       Date:  1996-12-27       Impact factor: 41.582

10.  Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.

Authors:  S R Ross; R A Graves; B M Spiegelman
Journal:  Genes Dev       Date:  1993-07       Impact factor: 11.361
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  28 in total

1.  Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype.

Authors:  K Moulin; N Truel; M André; E Arnauld; M Nibbelink; B Cousin; C Dani; L Pénicaud; L Casteilla
Journal:  Biochem J       Date:  2001-06-01       Impact factor: 3.857

Review 2.  Transcriptional and Epigenomic Regulation of Adipogenesis.

Authors:  Ji-Eun Lee; Hannah Schmidt; Binbin Lai; Kai Ge
Journal:  Mol Cell Biol       Date:  2019-05-14       Impact factor: 4.272

3.  Transcriptional control of adipose lipid handling by IRF4.

Authors:  Jun Eguchi; Xun Wang; Songtao Yu; Erin E Kershaw; Patricia C Chiu; Joanne Dushay; Jennifer L Estall; Ulf Klein; Eleftheria Maratos-Flier; Evan D Rosen
Journal:  Cell Metab       Date:  2011-03-02       Impact factor: 27.287

Review 4.  Improved methodologies for the study of adipose biology: insights gained and opportunities ahead.

Authors:  Qiong A Wang; Philipp E Scherer; Rana K Gupta
Journal:  J Lipid Res       Date:  2014-02-16       Impact factor: 5.922

5.  Biallelic Dicer1 Loss Mediated by aP2-Cre Drives Angiosarcoma.

Authors:  Jason A Hanna; Catherine J Drummond; Matthew R Garcia; Jonathan C Go; David Finkelstein; Jerold E Rehg; Mark E Hatley
Journal:  Cancer Res       Date:  2017-09-15       Impact factor: 12.701

6.  Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development.

Authors:  Matthew D Lynes; Tim J Schulz; Andrew J Pan; Yu-Hua Tseng
Journal:  Endocrinology       Date:  2015-01-27       Impact factor: 4.736

7.  Genetic Mouse Models: The Powerful Tools to Study Fat Tissues.

Authors:  Xingxing Kong; Kevin W Williams; Tiemin Liu
Journal:  Methods Mol Biol       Date:  2017

8.  A mouse model of rhabdomyosarcoma originating from the adipocyte lineage.

Authors:  Mark E Hatley; Wei Tang; Matthew R Garcia; David Finkelstein; Douglas P Millay; Ning Liu; Jonathan Graff; Rene L Galindo; Eric N Olson
Journal:  Cancer Cell       Date:  2012-10-16       Impact factor: 31.743

9.  Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.

Authors:  Harun Elmasri; Cagatay Karaaslan; Yaroslav Teper; Elisa Ghelfi; Meiqian Weng; Tan A Ince; Harry Kozakewich; Joyce Bischoff; Sule Cataltepe
Journal:  FASEB J       Date:  2009-07-22       Impact factor: 5.191

10.  Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues.

Authors:  Tizhong Shan; Weiyi Liu; Shihuan Kuang
Journal:  FASEB J       Date:  2012-10-09       Impact factor: 5.191
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