Literature DB >> 9166580

Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain.

D W Threadgill1, D Yee, A Matin, J H Nadeau, T Magnuson.   

Abstract

The 129 mouse is the most widely used strain in gene targeting experiments. However, numerous substrains exist with demonstrable physiological differences. In this study a set of simple sequence length polymorphisms (SSLPs) was used to determine the relatedness of selected 129 substrains. 129/SvJ was significantly different from the other 129 substrains and is more accurately classified as a recombinant congenic strain (129cX/Sv), being derived from 129/Sv and an unknown strain. This mixed genetic background could complicate gene targeting experiments by reducing homologous recombination efficiency when constructs and ES cells are not derived from the same 129 substrain. Additionally, discrepancies due to different genetic backgrounds may arise when comparing phenotypes of genes targeted in different 129-derived ES cell lines.

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Year:  1997        PMID： 9166580     DOI： 10.1007/s003359900453

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  15 in total

1.  Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

Authors:  H te Riele; E R Maandag; A Berns
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

2.  DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors.

Authors:  G B Collin; Y Asada; D S Varnum; J H Nadeau
Journal:  Mamm Genome       Date:  1996-01       Impact factor: 2.957

3.  SSLPs to map genetic differences between the 129 inbred strains and closed-colony, random-bred CD-1 mice.

Authors:  D W Threadgill; A Matin; D Yee; M M Carrasquillo; K R Henry; K G Rollins; J H Nadeau; T Magnuson
Journal:  Mamm Genome       Date:  1997-06       Impact factor: 2.957

4.  Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.

Authors:  B H Koller; L J Hagemann; T Doetschman; J R Hagaman; S Huang; P J Williams; N L First; N Maeda; O Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

5.  Transgenesis by means of blastocyst-derived embryonic stem cell lines.

Authors:  A Gossler; T Doetschman; R Korn; E Serfling; R Kemler
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

6.  The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.

Authors:  A P McMahon; A Bradley
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7.  Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

Authors:  D W Threadgill; A A Dlugosz; L A Hansen; T Tennenbaum; U Lichti; D Yee; C LaMantia; T Mourton; K Herrup; R C Harris
Journal:  Science       Date:  1995-07-14       Impact factor: 47.728

8.  The ter primordial germ cell deficiency mutation maps near Grl-1 on mouse chromosome 18.

Authors:  T Sakurai; H Katoh; K Moriwaki; T Noguchi; M Noguchi
Journal:  Mamm Genome       Date:  1994-06       Impact factor: 2.957

9.  A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18.

Authors:  Y Asada; D S Varnum; W N Frankel; J H Nadeau
Journal:  Nat Genet       Date:  1994-04       Impact factor: 38.330

10.  Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors.

Authors:  J van Deursen; B Wieringa
Journal:  Nucleic Acids Res       Date:  1992-08-11       Impact factor: 16.971
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  66 in total

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Authors:  J L Vilotte; P L'Huillier; J C Mercier
Journal:  J Mammary Gland Biol Neoplasia       Date:  1998-07       Impact factor: 2.673

2.  Strain-dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons.

Authors:  C W Shuttleworth; J A Connor
Journal:  J Neurosci       Date:  2001-06-15       Impact factor: 6.167

3.  Rapid generation of nested chromosomal deletions on mouse chromosome 2.

Authors:  D F LePage; D M Church; E Millie; T J Hassold; R A Conlon
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

4.  An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.

Authors:  Jay L Vivian; Yijing Chen; Della Yee; Elizabeth Schneider; Terry Magnuson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-13       Impact factor: 11.205

5.  Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice.

Authors:  Carol B Ware; La' Akea N Siverts; Angelique M Nelson; John F Morton; Warren C Ladiges
Journal:  Transgenic Res       Date:  2003-12       Impact factor: 2.788

Review 6.  Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function.

Authors:  Steven J Clapcote; John C Roder
Journal:  Genetics       Date:  2006-06-04       Impact factor: 4.562

7.  Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease.

Authors:  Alexander J Szalai; Xianzhen Hu; Jillian E Adams; Scott R Barnum
Journal:  Mol Immunol       Date:  2007-03-13       Impact factor: 4.407

8.  Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.

Authors:  Melanie Kahle; Marion Horsch; Barbara Fridrich; Anett Seelig; Jürgen Schultheiß; Jörn Leonhardt; Martin Irmler; Johannes Beckers; Birgit Rathkolb; Eckhard Wolf; Nicole Franke; Valérie Gailus-Durner; Helmut Fuchs; Martin Hrabě de Angelis; Susanne Neschen
Journal:  Mol Metab       Date:  2013-08-03       Impact factor: 7.422

9.  Genetically determined severity of anti-myeloperoxidase glomerulonephritis.

Authors:  Hong Xiao; Dominic Ciavatta; David L Aylor; Peiqi Hu; Fernando Pardo-Manuel de Villena; Ronald J Falk; J Charles Jennette
Journal:  Am J Pathol       Date:  2013-02-04       Impact factor: 4.307

10.  Efficient and fast targeted production of murine models based on ENU mutagenesis.

Authors:  M Augustin; R Sedlmeier; T Peters; U Huffstadt; E Kochmann; D Simon; M Schöniger; S Garke-Mayerthaler; J Laufs; M Mayhaus; S Franke; M Klose; A Graupner; M Kurzmann; C Zinser; A Wolf; M Voelkel; M Kellner; M Kilian; S Seelig; A Koppius; A Teubner; D Korthaus; M Nehls; S Wattler
Journal:  Mamm Genome       Date:  2005-06       Impact factor: 2.957
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