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Literature DB >> 16751659

Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function.

Abstract

We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.

Entities: Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16751659 PMCID： PMC1569715 DOI： 10.1534/genetics.106.060749

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

20 in total

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