Literature DB >> 9166220

Telomeres and telomerase: biological and clinical importance.

R Dahse1, W Fiedler, G Ernst.   

Abstract

We review the present knowledge of telomeres and telomerase with special attention to their role in cell proliferation, cellular senescence, and human aging. We summarize the functional aspects of telomerase in cancer, as well as its role as a useful diagnostic and prognostic tumor marker, and discuss possible approaches to telomerase inhibition as a target for cancer therapy.

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Year:  1997        PMID： 9166220

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  18 in total

1.  Telomerase immortalization of principal cells from mouse collecting duct.

Authors:  Stacy L Steele; Yongren Wu; Robert J Kolb; Monika Gooz; Courtney J Haycraft; Kent T Keyser; Lisa Guay-Woodford; Hai Yao; P Darwin Bell
Journal:  Am J Physiol Renal Physiol       Date:  2010-10-06

2.  Effect of antisense oligodeoxynucleotide of telomerase RNA on telomerase activity and cell apoptosis in human colon cancer.

Authors:  Ying-An Jiang; He-Sheng Luo; Li-Fang Fan; Chong-Qing Jiang; Wei-Jin Chen
Journal:  World J Gastroenterol       Date:  2004-02-01       Impact factor: 5.742

3.  Study of the expressions of p53 and bcl-2 genes, the telomerase activity and apoptosis in GIST patients.

Authors:  Qiang Wang; You-Wei Kou
Journal:  World J Gastroenterol       Date:  2007-05-14       Impact factor: 5.742

Review 4.  Social Ambivalence and Disease (SAD): A Theoretical Model Aimed at Understanding the Health Implications of Ambivalent Relationships.

Authors:  Julianne Holt-Lunstad; Bert N Uchino
Journal:  Perspect Psychol Sci       Date:  2019-09-18

5.  Telomerase activity detected by quantitative assay in bladder carcinoma and exfoliated cells in urine.

Authors:  R Fedriga; R Gunelli; O Nanni; F Bacci; D Amadori; D Calistri
Journal:  Neoplasia       Date:  2001 Sep-Oct       Impact factor: 5.715

6.  Telomerase activity and cell apoptosis in colon cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide.

Authors:  Ying-An Jiang; He-Sheng Luo; You-Yuan Zhang; Li-Fang Fan; Chong-Qing Jiang; Wei-Jin Chen
Journal:  World J Gastroenterol       Date:  2003-09       Impact factor: 5.742

7.  Inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell proliferation.

Authors:  Yun-Feng Piao; Yang Shi; Pu-Jun Gao
Journal:  World J Gastroenterol       Date:  2003-09       Impact factor: 5.742

8.  Feasibility of human telomerase reverse transcriptase mRNA expression in individual blastomeres as an indicator of early embryo development.

Authors:  Chia-Woei Wang; Ding-Shyan Yao; Shang-Gwo Horng; Hsiao-Chen Chiu; Chun-Kai Chen; Chyi-Long Lee; Hong-Yuan Huang; Hsin-Shih Wang; Yung-Kuei Soong; Chia C Pao
Journal:  J Assist Reprod Genet       Date:  2004-05       Impact factor: 3.412

9.  Quantum dots thermal stability improves simultaneous phenotype-specific telomere length measurement by FISH-flow cytometry.

Authors:  Veena Kapoor; Fran T Hakim; Najibah Rehman; Ronald E Gress; William G Telford
Journal:  J Immunol Methods       Date:  2009-03-05       Impact factor: 2.303

10.  Genetic variation exists for telomeric array organization within and among the genomes of normal, immortalized, and transformed chicken systems.

Authors:  Thomas H O'Hare; Mary E Delany
Journal:  Chromosome Res       Date:  2009-11-05       Impact factor: 5.239
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