Literature DB >> 9161051

HIV integrase: a target for AIDS therapeutics.

M Thomas1, L Brady.   

Abstract

HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.

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Year:  1997        PMID： 9161051     DOI： 10.1016/S0167-7799(97)01016-0

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  9 in total

1.  The identification of three novel genes involved in the rapid-growth regulation in a marine diatom, Skeletonema costatum.

Authors:  Chih-Ching Chung; Sheng-Ping L Hwang; Jeng Chang
Journal:  Mar Biotechnol (NY)       Date:  2008-10-08       Impact factor: 3.619

2.  Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.

Authors:  J Lubkowski; F Yang; J Alexandratos; A Wlodawer; H Zhao; T R Burke; N Neamati; Y Pommier; G Merkel; A M Skalka
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

3.  Exploring the binding of HIV-1 integrase inhibitors by comparative residue interaction analysis (CoRIA).

Authors:  Devendra K Dhaked; Jitender Verma; Anil Saran; Evans C Coutinho
Journal:  J Mol Model       Date:  2008-12-02       Impact factor: 1.810

4.  Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.

Authors:  Gregg S Jones; Fang Yu; Ameneh Zeynalzadegan; Joseph Hesselgesser; Xiaowu Chen; James Chen; Haolun Jin; Choung U Kim; Matthew Wright; Romas Geleziunas; Manuel Tsiang
Journal:  Antimicrob Agents Chemother       Date:  2008-12-22       Impact factor: 5.191

5.  Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and Their Inhibition.

Authors:  Murugesan Vanangamudi; Pramod C Nair; S E Maida Engels; Senthilkumar Palaniappan; Vigneshwaran Namasivayam
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

6.  Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches.

Authors:  Xavier Siwe-Noundou; Thommas M Musyoka; Vuyani Moses; Derek T Ndinteh; Dumisani Mnkandhla; Heinrich Hoppe; Özlem Tastan Bishop; Rui W M Krause
Journal:  Sci Rep       Date:  2019-03-18       Impact factor: 4.379

7.  Computational screening of inhibitors for HIV-1 integrase using a receptor based pharmacophore model.

Authors:  Janani Jaganatharaja; Ragul Gowthaman
Journal:  Bioinformation       Date:  2006-03-26

8.  Characterization of oligopeptide patterns in large protein sets.

Authors:  Anders Bresell; Bengt Persson
Journal:  BMC Genomics       Date:  2007-10-01       Impact factor: 3.969

9.  HIV-1 Integrase Inhibitory Effects of Major Compounds Present in CareVid™: An Anti-HIV Multi-Herbal Remedy.

Authors:  Winnie Rotich; Eduard Mas-Claret; Nicholas Sadgrove; Anastasia Guantai; Guillermo F Padilla-González; Moses K Langat
Journal:  Life (Basel)       Date:  2022-03-12
  9 in total

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