OBJECTIVE: To compare the methods used for diagnosis and the clinical features of non-specific inflammatory bowel disease (IBD) in the north and south of Europe. DESIGN: A prospective study over 2 years in 1991-3 at eight centres in the north and 12 in the south of Europe using the same criteria for disease definition and same protocol for recording data. SETTING:Specialist gastroenterological centres with good diagnostic facilities at which every effort was made to ascertain all new cases of IBD seen in other departments and primary care in a defined geographical area of known population. PARTICIPANTS: A total of 2201 patients newly diagnosed as suffering from IBD, 1397 with ulcerative colitis (UC), 706 with Crohn's disease (CD) and 116 with indeterminate colitis (IND). RESULTS: Diagnostic methods used were similar in north and south, a biopsy or resection specimen was available for examination in 94 and 95%, of cases of UC and 92 and 87% of CD in north and south, respectively. The type, clinical presentation, site and extent of disease were similar in north and south. Treatment followed a common pattern and mortality from IBD was low in the first year after diagnosis. In both areas, age of onset of UC tended to be later than CD. CONCLUSION: The standard of diagnosis and clinical features of IBD are similar in specialist centres throughout Europe so providing a valid basis for this aspect of collaborative epidemiological or other studies.
RCT Entities:
OBJECTIVE: To compare the methods used for diagnosis and the clinical features of non-specific inflammatory bowel disease (IBD) in the north and south of Europe. DESIGN: A prospective study over 2 years in 1991-3 at eight centres in the north and 12 in the south of Europe using the same criteria for disease definition and same protocol for recording data. SETTING: Specialist gastroenterological centres with good diagnostic facilities at which every effort was made to ascertain all new cases of IBD seen in other departments and primary care in a defined geographical area of known population. PARTICIPANTS: A total of 2201 patients newly diagnosed as suffering from IBD, 1397 with ulcerative colitis (UC), 706 with Crohn's disease (CD) and 116 with indeterminate colitis (IND). RESULTS: Diagnostic methods used were similar in north and south, a biopsy or resection specimen was available for examination in 94 and 95%, of cases of UC and 92 and 87% of CD in north and south, respectively. The type, clinical presentation, site and extent of disease were similar in north and south. Treatment followed a common pattern and mortality from IBD was low in the first year after diagnosis. In both areas, age of onset of UC tended to be later than CD. CONCLUSION: The standard of diagnosis and clinical features of IBD are similar in specialist centres throughout Europe so providing a valid basis for this aspect of collaborative epidemiological or other studies.
Authors: Frank L Wolters; Gilbert van Zeijl; Jildou Sijbrandij; Frederik Wessels; Colm O'Morain; Charles Limonard; Maurice G Russel; Reinhold W Stockbrugger Journal: World J Gastroenterol Date: 2005-12-07 Impact factor: 5.742
Authors: E F Stange; S P L Travis; S Vermeire; C Beglinger; L Kupcinkas; K Geboes; A Barakauskiene; V Villanacci; A Von Herbay; B F Warren; C Gasche; H Tilg; Stefan W Schreiber; J Schölmerich; W Reinisch Journal: Gut Date: 2006-03 Impact factor: 23.059
Authors: Jan Wehkamp; Martin Götz; Klaus Herrlinger; Wolfgang Steurer; Eduard F Stange Journal: Dtsch Arztebl Int Date: 2016-02-05 Impact factor: 5.594
Authors: O Höie; L J Schouten; F L Wolters; I C Solberg; L Riis; I A Mouzas; P Politi; S Odes; E Langholz; M Vatn; R W Stockbrügger; B Moum Journal: Gut Date: 2006-10-06 Impact factor: 23.059
Authors: F Molinié; C Gower-Rousseau; T Yzet; V Merle; B Grandbastien; R Marti; E Lerebours; J-L Dupas; J-F Colombel; J-L Salomez; A Cortot Journal: Gut Date: 2004-06 Impact factor: 23.059