Literature DB >> 9159741

G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.

T Xie1, S L Ho, L S Li, O C Ma.   

Abstract

High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.

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Year:  1997        PMID： 9159741     DOI： 10.1002/mds.870120325

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  8 in total

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2.  Genetic predictors for acute experimental cold and heat pain sensitivity in humans.

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4.  Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population.

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Journal:  BMC Neurol       Date:  2011-07-25       Impact factor: 2.474

5.  Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.

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Review 6.  Genetic influences on smoking: candidate genes.

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Journal:  BMC Med Genomics       Date:  2017-09-19       Impact factor: 3.063

8.  Polymorphism of the COMT, MAO, DAT, NET and 5-HTT Genes, and Biogenic Amines in Parkinson's Disease.

Authors:  Jolanta Dorszewska; Michal Prendecki; Anna Oczkowska; Agata Rozycka; Margarita Lianeri; Wojciech Kozubski
Journal:  Curr Genomics       Date:  2013-12       Impact factor: 2.236
  8 in total

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