| Literature DB >> 915911 |
E J Valente, E C Lingafelter, W R Porter, W F Trager.
Abstract
Warfarin in solution is shown to consist of three interconverting tautomeric structures, two of which are cyclic diastereomeric hemiketals, while the third and minor component is the open-chain intermediate form. The configurations of all the tautomers as well as the major conformations of the cyclic tautomers are assigned. The assignments are supported by comparison with the chemical shift and coupling constant parameters of structurally fixed model compounds.Entities:
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Year: 1977 PMID： 915911 DOI： 10.1021/jm00221a025
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446