| Literature DB >> 915906 |
M Bodanszky, J B Henes, A E Yiotakis, S I Said.
Abstract
The decapeptide derivative, L-histidyl-L-seryl-L-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-aspartyl-L-asparaginyl-L-tyrosine methyl ester, corresponding to the N-terminal sequence of both porcine and chicken VIP was synthesized in solution, by the stepwise strategy. Its pharmacological properties resemble those of VIP itself, but with a much lower potency, comparable to that of peptides with C-terminal sequences. The presence of two independent sequences carrying similar instructions was recognized in VIP.Entities:
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Year: 1977 PMID： 915906 DOI： 10.1021/jm00221a019
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446