BACKGROUND AND PURPOSE: The internal carotid (ICA) and external carotid (ECA) contributions to changing concentrations of oxyhemoglobin (Hbo2) and deoxyhemoglobin (Hb) during carotid endarterectomy were assessed with the use of near-infrared spectroscopy (NIRS). METHODS: NIRS optodes were placed on the forehead with an interoptode distance of 6 cm, and laser-Doppler flowmetry (LDF) was used to monitor the change in skin blood flow between the optodes. Hb, Hbo2, LDF, arterial blood pressure, and middle cerebral artery flow velocity were recorded continuously. The ECA was clamped 2 minutes before the ICA was clamped. Suitable multimodal recordings were achieved in 44 patients. RESULTS: When the ECA was clamped, 76% of patients showed a fall in Hbo2 and 65% an increase in Hb. When corrected for changes in arterial blood pressure, an accompanying fall in cutaneous LDF predicted the fall in Hbo2 with high sensitivity (100%) and specificity (100%). Among those with no NIRS changes during ECA clamping, 56% had severe ECA stenosis or occlusion; none of these showed an accompanying fall in LDF. In contrast, when the ICA was clamped, substantial additional changes in NIRS occurred in 55% of cases, all of which were associated with a fall in flow velocity, but none with a change in LDF. Patients with a constant flow velocity after ICA clamping also showed no change in NIRS. CONCLUSIONS: Both the ECA and ICA vascular territories contribute to NIRS changes during carotid endarterectomy. The external carotid contribution to NIRS can be monitored with cutaneous LDF.
BACKGROUND AND PURPOSE: The internal carotid (ICA) and external carotid (ECA) contributions to changing concentrations of oxyhemoglobin (Hbo2) and deoxyhemoglobin (Hb) during carotid endarterectomy were assessed with the use of near-infrared spectroscopy (NIRS). METHODS: NIRS optodes were placed on the forehead with an interoptode distance of 6 cm, and laser-Doppler flowmetry (LDF) was used to monitor the change in skin blood flow between the optodes. Hb, Hbo2, LDF, arterial blood pressure, and middle cerebral artery flow velocity were recorded continuously. The ECA was clamped 2 minutes before the ICA was clamped. Suitable multimodal recordings were achieved in 44 patients. RESULTS: When the ECA was clamped, 76% of patients showed a fall in Hbo2 and 65% an increase in Hb. When corrected for changes in arterial blood pressure, an accompanying fall in cutaneous LDF predicted the fall in Hbo2 with high sensitivity (100%) and specificity (100%). Among those with no NIRS changes during ECA clamping, 56% had severe ECA stenosis or occlusion; none of these showed an accompanying fall in LDF. In contrast, when the ICA was clamped, substantial additional changes in NIRS occurred in 55% of cases, all of which were associated with a fall in flow velocity, but none with a change in LDF. Patients with a constant flow velocity after ICA clamping also showed no change in NIRS. CONCLUSIONS: Both the ECA and ICA vascular territories contribute to NIRS changes during carotid endarterectomy. The external carotid contribution to NIRS can be monitored with cutaneous LDF.
Authors: Karol P Budohoski; Marek Czosnyka; Peter J Kirkpatrick; Peter Smielewski; Luzius A Steiner; John D Pickard Journal: Nat Rev Neurol Date: 2013-02-19 Impact factor: 42.937
Authors: David J Davies; Zhangjie Su; Michael T Clancy; Samuel J E Lucas; Hamid Dehghani; Ann Logan; Antonio Belli Journal: J Neurotrauma Date: 2015-04-17 Impact factor: 5.269
Authors: Christina Kolyva; Arnab Ghosh; Ilias Tachtsidis; David Highton; Chris E Cooper; Martin Smith; Clare E Elwell Journal: Neuroimage Date: 2013-05-23 Impact factor: 6.556