| Literature DB >> 9157190 |
J Gerard1, R Lloyd, T Barsby, P Haden, M T Kelly, R J Andersen.
Abstract
Massetolides A-H (1-8), novel cyclic depsipeptides, and the known compound viscosin (9) have been isolated from cultures of two Pseudomonas sp. isolated from a marine alga and a marine tube worm, respectively. Massetolide A (1) and viscosin (9) exhibit in vitro antimicrobial activity against Mycobacterium tuberculosis and Mycobacterium avium-intracellulare. Precursor-directed biosynthesis has been used to generate unnatural massetolides 11-13 incorporating nonprotein amino acids.Entities:
Mesh:
Substances:
Year: 1997 PMID: 9157190 DOI: 10.1021/np9606456
Source DB: PubMed Journal: J Nat Prod ISSN: 0163-3864 Impact factor: 4.050