| Literature DB >> 9152988 |
K Blum1, E R Braverman, S Wu, J G Cull, T J Chen, J Gill, R Wood, A Eisenberg, M Sherman, K R Davis, D Matthews, L Fischer, N Schnautz, W Walsh, A A Pontius, M Zedar, G Kaats, D E Comings.
Abstract
The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D2 receptor Taq A1 allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT1) gene with SAB was similarly found.Entities:
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Year: 1997 PMID： 9152988 DOI： 10.1038/sj.mp.4000261
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992