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Literature DB >> 13678562

Genetic polymorphisms in the expression and treatment of neuropsychiatric disorders.

Abstract

Recent advances in molecular genetics have greatly increased the understanding of the pathophysiology of certain neurobehavioral disorders and the core symptoms of these disorders. This paper reviews key concepts important in understanding the genetics of neuropsychiatric disorders, and gives an overview of several different types of genetic disorders, including trinucleotide repeat disorders, and functional polymorphisms of monoamine neurotransmitter systems.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2003 PMID： 13678562 DOI： 10.1007/s11920-003-0075-4

Source DB: PubMed Journal: Curr Psychiatry Rep ISSN： 1523-3812 Impact factor: 5.285

69 in total

1. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1.

Authors: D E Comings; S Wu; C Chiu; R H Ring; R Gade; C Ahn; J P MacMurray; G Dietz; D Muhleman
Journal: Am J Med Genet Date: 1996-05-31

2. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers.

Authors: E G Jönsson; M M Nöthen; F Grünhage; L Farde; Y Nakashima; P Propping; G C Sedvall
Journal: Mol Psychiatry Date: 1999-05 Impact factor: 15.992

Review 3. Prefrontal neurons and the genetics of schizophrenia.

Authors: D R Weinberger; M F Egan; A Bertolino; J H Callicott; V S Mattay; B K Lipska; K F Berman; T E Goldberg
Journal: Biol Psychiatry Date: 2001-12-01 Impact factor: 13.382

4. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.

Authors: Venkata S Mattay; Terry E Goldberg; Francesco Fera; Ahmad R Hariri; Alessandro Tessitore; Michael F Egan; Bhaskar Kolachana; Joseph H Callicott; Daniel R Weinberger
Journal: Proc Natl Acad Sci U S A Date: 2003-04-25 Impact factor: 11.205

5. Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study.

Authors: Luis A Rohde; Tatiana Roman; Claudia Szobot; Renato D Cunha; Mara H Hutz; Joseph Biederman
Journal: Synapse Date: 2003-05 Impact factor: 2.562

6. Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders.

Authors: G Stöber; M M Nöthen; P Pörzgen; M Brüss; H Bönisch; M Knapp; H Beckmann; P Propping
Journal: Am J Med Genet Date: 1996-11-22

7. Normalization of auditory physiology by cigarette smoking in schizophrenic patients.

Authors: L E Adler; L D Hoffer; A Wiser; R Freedman
Journal: Am J Psychiatry Date: 1993-12 Impact factor: 18.112

8. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity.

Authors: I D Waldman; D C Rowe; A Abramowitz; S T Kozel; J H Mohr; S L Sherman; H H Cleveland; M L Sanders; J M Gard; C Stever
Journal: Am J Hum Genet Date: 1998-12 Impact factor: 11.025

Genetic polymorphisms in the expression and treatment of neuropsychiatric disorders.

1. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1.

2. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers.

Review 3. Prefrontal neurons and the genetics of schizophrenia.

4. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.

5. Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study.

6. Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders.

7. Normalization of auditory physiology by cigarette smoking in schizophrenic patients.

8. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity.

9. A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association.

Review 10. Schizophrenia, sensory gating, and nicotinic receptors.

1. Animal models of gene-environment interactions in schizophrenia.

Review 2. Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments.

3. Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients.

4. Polymorphisms of Dopamine Receptor Genes and Risk of L-Dopa-Induced Dyskinesia in Parkinson's Disease.