Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.

Literature DB >> 9151883

Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest.

L Selig¹, S Benichou, M E Rogel, L I Wu, M A Vodicka, J Sire, R Benarous, M Emerman.

Abstract

The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G2 arrest). The cellular target for these functions is not known, but Vpr of HIV-1 and the related Vpr from simian immunodeficiency virus of sooty mangabeys (SIV(SM)) bind the DNA repair enzyme UNG, while the Vpx protein of SIV(SM) does not. Nonetheless, a mutational analysis of Vpr showed that binding to UNG is neither necessary nor sufficient for the effect of Vpr on the cell cycle.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1997 PMID： 9151883 PMCID： PMC191711

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

29 in total

1. Incorporation of uracil into viral DNA correlates with reduced replication of EIAV in macrophages.

Authors: W K Steagall; M D Robek; S T Perry; F J Fuller; S L Payne
Journal: Virology Date: 1995-07-10 Impact factor: 3.616

2. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.

Authors: J He; S Choe; R Walker; P Di Marzio; D O Morgan; N R Landau
Journal: J Virol Date: 1995-11 Impact factor: 5.103

3. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.

Authors: F Re; D Braaten; E K Franke; J Luban
Journal: J Virol Date: 1995-11 Impact factor: 5.103

4. Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.

Authors: J W Balliet; D L Kolson; G Eiger; F M Kim; K A McGann; A Srinivasan; R Collman
Journal: Virology Date: 1994-05-01 Impact factor: 3.616

5. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

Authors: N K Heinzinger; M I Bukrinsky; S A Haggerty; A M Ragland; V Kewalramani; M A Lee; H E Gendelman; L Ratner; M Stevenson; M Emerman
Journal: Proc Natl Acad Sci U S A Date: 1994-07-19 Impact factor: 11.205

6. Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.

Authors: G Slupphaug; I Eftedal; B Kavli; S Bharati; N M Helle; T Haug; D W Levine; H E Krokan
Journal: Biochemistry Date: 1995-01-10 Impact factor: 3.162

7. Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replication.

Authors: V M Hirsch; G Dapolito; P R Johnson; W R Elkins; W T London; R J Montali; S Goldstein; C Brown
Journal: J Virol Date: 1995-02 Impact factor: 5.103

8. The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.

Authors: J B Jowett; V Planelles; B Poon; N P Shah; M L Chen; I S Chen
Journal: J Virol Date: 1995-10 Impact factor: 5.103

9. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes.

Authors: R I Connor; B K Chen; S Choe; N R Landau
Journal: Virology Date: 1995-02-01 Impact factor: 3.616

10. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.

Authors: P Di Marzio; S Choe; M Ebright; R Knoblauch; N R Landau
Journal: J Virol Date: 1995-12 Impact factor: 5.103

65 in total

Review 1. Human immunodeficiency virus and AIDS: insights from animal lentiviruses.

Authors: R J Miller; J S Cairns; S Bridges; N Sarver
Journal: J Virol Date: 2000-08 Impact factor: 5.103

2. The first HxRxG motif in simian immunodeficiency virus mac239 Vpr is crucial for G(2)/M cell cycle arrest.

Authors: Sandra M Mueller; Sabine M Lang
Journal: J Virol Date: 2002-11 Impact factor: 5.103

3. Evidence for a cytopathogenicity determinant in HIV-1 Vpr.

Authors: Mohan Somasundaran; Mark Sharkey; Beda Brichacek; Katherine Luzuriaga; Michael Emerman; John L Sullivan; Mario Stevenson
Journal: Proc Natl Acad Sci U S A Date: 2002-07-01 Impact factor: 11.205

4. Inhibition of tRNA₃(Lys)-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication.

Authors: Fei Guo; Shan Cen; Meijuan Niu; Jenan Saadatmand; Lawrence Kleiman
Journal: J Virol Date: 2006-09-13 Impact factor: 5.103

5. Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G.

Authors: Shari M Kaiser; Michael Emerman
Journal: J Virol Date: 2006-01 Impact factor: 5.103

6. HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.

Authors: Jinwoo Ahn; Thomas Vu; Zach Novince; Jennifer Guerrero-Santoro; Vesna Rapic-Otrin; Angela M Gronenborn
Journal: J Biol Chem Date: 2010-09-24 Impact factor: 5.157