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Literature DB >> 20347598

The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.

Laurieann Casey¹, Xiaoyun Wen, Carlos M C de Noronha.

Abstract

Among the proteins encoded by human and simian immunodeficiency viruses (HIV and SIV) at least three, Vif, Vpu and Vpr, subvert cellular ubiquitin ligases to block the action of anti-viral defenses. This review focuses on Vpr and its HIV2/SIV counterparts, Vpx and Vpr, which all engage the DDB1.Cullin4 ubiquitin ligase complex through the DCAF1 adaptor protein. Here, we discuss the multiple functions that have been linked to Vpr expression and summarize the current knowledge on the role of the ubiquitin ligase complex in carrying out a subset of these activities. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year: 2010 PMID： 20347598 PMCID： PMC2880205 DOI： 10.1016/j.cyto.2010.02.018

Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861

132 in total

1. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

Authors: Stephane Angers; Ti Li; Xianhua Yi; Michael J MacCoss; Randall T Moon; Ning Zheng
Journal: Nature Date: 2006-10-05 Impact factor: 49.962

2. Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function.

Authors: Narasimhan J Venkatachari; Biswanath Majumder; Velpandi Ayyavoo
Journal: Virology Date: 2006-10-04 Impact factor: 3.616

3. Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.

Authors: Erik S Zimmerman; Michael P Sherman; Jana L Blackett; Jason A Neidleman; Christophe Kreis; Pamela Mundt; Samuel A Williams; Maria Warmerdam; James Kahn; Frederick M Hecht; Robert M Grant; Carlos M C de Noronha; Andrew S Weyrich; Warner C Greene; Vicente Planelles
Journal: J Virol Date: 2006-09-06 Impact factor: 5.103

4. HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.

Authors: Erwann Le Rouzic; Nadia Belaïdouni; Emilie Estrabaud; Marina Morel; Jean-Christophe Rain; Catherine Transy; Florence Margottin-Goguet
Journal: Cell Cycle Date: 2007-01-17 Impact factor: 4.534

5. Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.

Authors: J W Balliet; D L Kolson; G Eiger; F M Kim; K A McGann; A Srinivasan; R Collman
Journal: Virology Date: 1994-05-01 Impact factor: 3.616

6. Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.

Authors: S Anderson; D C Shugars; R Swanstrom; J V Garcia
Journal: J Virol Date: 1993-08 Impact factor: 5.103

7. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

Authors: N K Heinzinger; M I Bukrinsky; S A Haggerty; A M Ragland; V Kewalramani; M A Lee; H E Gendelman; L Ratner; M Stevenson; M Emerman
Journal: Proc Natl Acad Sci U S A Date: 1994-07-19 Impact factor: 11.205

8. HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.

Authors: Bärbel Schröfelbauer; Yoshiyuki Hakata; Nathaniel R Landau
Journal: Proc Natl Acad Sci U S A Date: 2007-02-28 Impact factor: 11.205

9. Down-regulation of CD4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surfaces.

Authors: M Inoue; Y Koga; D Djordjijevic; T Fukuma; E P Reddy; M M Yokoyama; K Sagawa
Journal: Int Immunol Date: 1993-09 Impact factor: 4.823

10. HIV infection of non-dividing cells: a divisive problem.

Authors: Ariberto Fassati
Journal: Retrovirology Date: 2006-10-26 Impact factor: 4.602

18 in total

1. Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.

Authors: Baek Kim; Laura A Nguyen; Waaqo Daddacha; Joseph A Hollenbaugh
Journal: J Biol Chem Date: 2012-05-14 Impact factor: 5.157

The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.

1. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

2. Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function.

3. Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.

4. HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.

5. Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.

6. Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.

7. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

8. HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.

9. Down-regulation of CD4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surfaces.

10. HIV infection of non-dividing cells: a divisive problem.

1. Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.

Review 2. The restriction factors of human immunodeficiency virus.

3. Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.

Review 4. Changing the ubiquitin landscape during viral manipulation of the DNA damage response.

Review 5. Host restriction factors in retroviral infection: promises in virus-host interaction.

Review 6. HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention.

7. Viral takeover of the host ubiquitin system.

8. HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction.

9. CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

10. Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.