| Literature DB >> 9150444 |
E P Böttinger1, J J Letterio, A B Roberts.
Abstract
This paper reviews the basic biology and biochemistry of the TGF-beta isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or receptor/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-beta 1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.Entities:
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Year: 1997 PMID： 9150444 DOI： 10.1038/ki.1997.185
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612