Literature DB >> 11035768

Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice.

K A Wilkinson1, T D Martin, S M Reba, H Aung, R W Redline, W H Boom, Z Toossi, S A Fulton.   

Abstract

Latency-associated peptide of transforming growth factor beta (TGF-beta) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta.

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Year:  2000        PMID： 11035768      PMCID： PMC97742          DOI： 10.1128/IAI.68.11.6505-6508.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

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Journal:  J Immunol       Date:  1987-01-01       Impact factor: 5.422

Review 2.  Activation of latent transforming growth factor beta.

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Authors:  S Tsunawaki; M Sporn; A Ding; C Nathan
Journal:  Nature       Date:  1988-07-21       Impact factor: 49.962

4.  Pulmonary immune responses during primary mycobacterium bovis- Calmette-Guerin bacillus infection in C57Bl/6 mice.

Authors:  S A Fulton; T D Martin; R W Redline; W Henry Boom
Journal:  Am J Respir Cell Mol Biol       Date:  2000-03       Impact factor: 6.914

5.  Effects of modulating TGF-beta 1 on immune responses to mycobacterial infection in guinea pigs.

Authors:  G Dai; D N McMurray
Journal:  Tuber Lung Dis       Date:  1999

6.  Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis.

Authors:  I Flesch; S H Kaufmann
Journal:  J Immunol       Date:  1987-06-15       Impact factor: 5.422

7.  Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 mRNA and protein in the murine lung.

Authors:  R W Pelton; M D Johnson; E A Perkett; L I Gold; H L Moses
Journal:  Am J Respir Cell Mol Biol       Date:  1991-12       Impact factor: 6.914

8.  Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

Authors:  J L Flynn; M M Goldstein; K J Triebold; B Koller; B R Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

9.  Granuloma formation in severe combined immunodeficient (SCID) mice in response to progressive BCG infection. Tendency not to form granulomas in the lung is associated with faster bacterial growth in this organ.

Authors:  R J North; A A Izzo
Journal:  Am J Pathol       Date:  1993-06       Impact factor: 4.307

10.  Evidence for an alpha/beta T cell-independent mechanism of resistance to mycobacteria. Bacillus-Calmette-Guerin causes progressive infection in severe combined immunodeficient mice, but not in nude mice or in mice depleted of CD4+ and CD8+ T cells.

Authors:  A A Izzo; R J North
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307
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  6 in total

Review 1.  Reversal of tumor-induced immunosuppression by TGF-beta inhibitors.

Authors:  Slawomir Wojtowicz-Praga
Journal:  Invest New Drugs       Date:  2003-02       Impact factor: 3.850

2.  Enhanced antimycobacterial response to recombinant Mycobacterium bovis BCG expressing latency-associated peptide.

Authors:  B G Marshall; A Wangoo; P O'Gaora; H T Cook; R J Shaw; D B Young
Journal:  Infect Immun       Date:  2001-11       Impact factor: 3.441

3.  Inhibition of Mycobacterium tuberculosis-induced signalling by transforming growth factor-β in human mononuclear phagocytes.

Authors:  M Wu; H Aung; C S Hirsch; Z Toossi
Journal:  Scand J Immunol       Date:  2012-03       Impact factor: 3.487

4.  Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses.

Authors:  Timothy Stachowski; Thomas D Grant; Edward H Snell
Journal:  J Synchrotron Radiat       Date:  2019-06-13       Impact factor: 2.616

Review 5.  Target the Host, Kill the Bug; Targeting Host Respiratory Immunosuppressive Responses as a Novel Strategy to Improve Bacterial Clearance During Lung Infection.

Authors:  Alanna M Kelly; Rachel M McLoughlin
Journal:  Front Immunol       Date:  2020-04-30       Impact factor: 7.561

6.  Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states.

Authors:  Timothy R Stachowski; Mary E Snell; Edward H Snell
Journal:  IUCrJ       Date:  2020-02-06       Impact factor: 4.769
  6 in total

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