C L Parsons1. 1. Division of Urology, University of California at San Diego Medical Center, USA.
Abstract
OBJECTIVES: To review the newer methods of treatment of interstitial cystitis using techniques that coat the epithelium to maintain its integrity relative to permeability. METHODS: The technique of employing sulfated polysaccharides in the treatment of interstitial cystitis both orally and intravesically were reviewed as well as the concepts supporting the use of such technology, including a review of the role glycosaminoglycans (mucus) play in the regulation of epithelial permeability. Also reviewed were the methods that can be employed to detect aberrations of epithelial permeability as seen in the interstitial cystitis syndrome. RESULTS: The techniques of detecting epithelial permeability problems and appropriate therapy for this using polysaccharides, such as heparin and pentosanpolysulfate, are presented. This article also discusses the point that these techniques will result in long-term remissions in patients with the IC syndrome who respond to these treatments. CONCLUSIONS: The use of sulfated polysaccharides, both orally and intravesically, is an effective long-term treatment for many people with the interstitial cystitis syndrome.
OBJECTIVES: To review the newer methods of treatment of interstitial cystitis using techniques that coat the epithelium to maintain its integrity relative to permeability. METHODS: The technique of employing sulfated polysaccharides in the treatment of interstitial cystitis both orally and intravesically were reviewed as well as the concepts supporting the use of such technology, including a review of the role glycosaminoglycans (mucus) play in the regulation of epithelial permeability. Also reviewed were the methods that can be employed to detect aberrations of epithelial permeability as seen in the interstitial cystitis syndrome. RESULTS: The techniques of detecting epithelial permeability problems and appropriate therapy for this using polysaccharides, such as heparin and pentosanpolysulfate, are presented. This article also discusses the point that these techniques will result in long-term remissions in patients with the IC syndrome who respond to these treatments. CONCLUSIONS: The use of sulfated polysaccharides, both orally and intravesically, is an effective long-term treatment for many people with the interstitial cystitis syndrome.
Authors: Paul J Hauser; David A Buethe; John Califano; Troy M Sofinowski; Daniel J Culkin; Robert E Hurst Journal: J Urol Date: 2009-09-17 Impact factor: 7.450