Literature DB >> 9145529

Synthesis by an alpha-glucosidase of glycosyl-trehaloses with an isomaltosyl residue.

M Kurimoto1, T Nishimoto, T Nakada, H Chaen, S Fukuda, Y Tsujisaka.   

Abstract

Glycosyl-trehaloses with an isomaltosyl residue were synthesized by alpha-glucosidase from Aspergillus niger by using maltotetraose as a glucosyl donor and trehalose as the acceptor. The one trisaccharide and two tetrasaccharides formed were isolated by successive column chromatography. The results of an enzymatic digestion, methylation analysis, and 13C-NMR studies indicated that these oligosaccharides were alpha-isomaltosyl alpha-glucoside, alpha-isomaltotriosyl alpha-glucoside and alpha-isomaltoside. These oligosaccharides were not fermented to an acid by Streptococcus mutans, and they effectively inhibited water-insoluble glucan synthesis from sucrose by glucosyltransferase. In an in vitro utilization test with human intestinal bacteria, these oligosaccharides were predominantly utilized by Bifidobacteria.

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Year:  1997        PMID： 9145529     DOI： 10.1271/bbb.61.699

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

1.  Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs.

Authors:  Toshinori Sako; Akihiro Mori; Peter Lee; Hiroshi Goto; Hiroko Fukuta; Hitomi Oda; Kaori Saeki; Yohei Miki; Yuki Makino; Katsumi Ishioka; Hisashi Mizutani; Yuzo Kojima; Satoshi Koikeda; Toshiro Arai
Journal:  Vet Res Commun       Date:  2010-02-18       Impact factor: 2.459

2.  Crystallization and preliminary X-ray crystallographic analysis of α-glucosidase HaG from Halomonas sp. strain H11.

Authors:  Xing Shen; Wataru Saburi; Zuo-Qi Gai; Keisuke Komoda; Jian Yu; Teruyo Ojima-Kato; Yusuke Kido; Hirokazu Matsui; Haruhide Mori; Min Yao
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-03-25       Impact factor: 1.056

3.  Oligosaccharide composition and pheromonal activity of male tergal gland secretions of the German cockroach, Blattella gennanica (L.).

Authors:  Satoshi Nojima; Soichi Kugimiya; Ritsuo Nishida; Masayuki Sakuma; Yasumasa Kuwahara
Journal:  J Chem Ecol       Date:  2002-07       Impact factor: 2.626

4.  Transglucosidase improves the gut microbiota profile of type 2 diabetes mellitus patients: a randomized double-blind, placebo-controlled study.

Authors:  Makoto Sasaki; Naotaka Ogasawara; Yasushi Funaki; Mari Mizuno; Akihito Iida; Chiho Goto; Satoshi Koikeda; Kunio Kasugai; Takashi Joh
Journal:  BMC Gastroenterol       Date:  2013-05-08       Impact factor: 3.067

5.  Synthesis of isobemisiose, neosartose, and fischerose: three α-1,6-linked trehalose-based oligosaccharides identified from Neosartorya fischeri.

Authors:  E J Kuenstner; E A Palumbo; J Levine; N L Snyder
Journal:  RSC Adv       Date:  2020-06-12       Impact factor: 4.036

6.  A novel strategy in production of oligosaccharides in digestive tract: prevention of postprandial hyperglycemia and hyperinsulinemia.

Authors:  Makoto Sasaki; Takashi Joh; Satoshi Koikeda; Hiromi Kataoka; Satoshi Tanida; Tadayuki Oshima; Naotaka Ogasawara; Hirotaka Ohara; Haruhisa Nakao; Takeshi Kamiya
Journal:  J Clin Biochem Nutr       Date:  2007-11       Impact factor: 3.114

7.  Evaluation and directed evolution for thermostability improvement of a GH 13 thermostable α-glucosidase from Thermus thermophilus TC11.

Authors:  Cheng Zhou; Yanfen Xue; Yanhe Ma
Journal:  BMC Biotechnol       Date:  2015-10-21       Impact factor: 2.563
  7 in total

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