| Literature DB >> 9141213 |
M Canales1, A Enríquez, E Ramos, D Cabrera, H Dandie, A Soto, V Falcón, M Rodríguez, J de la Fuente.
Abstract
A gene coding for the Bm86 tick protein was recently cloned, expressed in Pichia pastoris and shown to induce an inmunological response in cattle against ticks. Moreover, the Gavac vaccine (Heber Biotec S.A., Havana, Cuba), which contains this recombinant protein, has proved to control the Boophilus microplus populations under field conditions. This paper reviews the development and large-scale production of this vaccine, the efficacy of the resulting product and the strategy followed in designing its production plant. The production plant fulfills biosafety requirements and GMP.Entities:
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Year: 1997 PMID： 9141213 DOI： 10.1016/s0264-410x(96)00192-2
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641