Literature DB >> 9138674

Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin.

H J Patel1, M A Giembycz, L Spicuzza, P J Barnes, M G Belvisi.   

Abstract

The novel peptide, nociceptin and the mu-opioid agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO) produced a concentration-dependent inhibition of electrical field stimulation (EFS)-evoked release of acetylcholine (ACh) from cholinergic nerves innervating guinea-pig trachea. The non-selective opioid receptor antagonist, naloxone, did not antagonize the inhibitory action of nociceptin under conditions where the inhibition of ACh release evoked by DAMGO was completely reversed. It is suggested that DAMGO and nociceptin can inhibit cholinergic, parasympathetic neurotransmission to the airways via the activation of classical (naloxone-sensitive) and novel (naloxone-insensitive) opioid receptors, respectively.

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Year:  1997        PMID： 9138674      PMCID： PMC1564553          DOI： 10.1038/sj.bjp.0701013

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle.

Authors:  M Ho; A D Corbett; A T McKnight
Journal:  Br J Pharmacol       Date:  2000-09       Impact factor: 8.739

2.  Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma.

Authors:  Shailendra R Singh; Nikol Sullo; Maria Matteis; Giuseppe Spaziano; John McDonald; Ruth Saunders; Lucy Woodman; Konrad Urbanek; Antonella De Angelis; Raffaele De Palma; Rachid Berair; Mitesh Pancholi; Vijay Mistry; Francesco Rossi; Remo Guerrini; Girolamo Calò; Bruno D'Agostino; Christopher E Brightling; David G Lambert
Journal:  Br J Pharmacol       Date:  2016-03-06       Impact factor: 8.739

Review 3.  Pharmacology of nociceptin and its receptor: a novel therapeutic target.

Authors:  G Calo'; R Guerrini; A Rizzi; S Salvadori; D Regoli
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

4.  Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors.

Authors:  H Okawa; B Nicol; R Bigoni; R A Hirst; G Calo; R Guerrini; D J Rowbotham; D Smart; A T McKnight; D G Lambert
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

5.  Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.

Authors:  Bruno D'Agostino; Giuseppina Marrocco; Marilisa De Nardo; Girolamo Calò; Remo Guerrini; Luca Gallelli; Charles Advenier; Francesco Rossi
Journal:  Br J Pharmacol       Date:  2005-03       Impact factor: 8.739

6.  Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus.

Authors:  A Fischer; B J Undem
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

7.  Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel.

Authors:  Yanlin Jia; Xin Wang; Sonia I Aponte; Maria A Rivelli; Richard Yang; Charles A Rizzo; Michel R Corboz; Tony Priestley; John A Hey
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

8.  Nociceptin inhibits vanilloid TRPV-1-mediated neurosensitization induced by fenoterol in human isolated bronchi.

Authors:  Christophe Faisy; Emmanuel Naline; Céline Rouget; Paul-André Risse; Emmanuel Guerot; Jean-Yves Fagon; Thierry Chinet; Nicolas Roche; Charles Advenier
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-09-04       Impact factor: 3.000

9.  Effects of nociceptin/orphanin FQ receptor ligands on blood pressure, heart rate, and plasma catecholamine concentrations in guinea pigs.

Authors:  Eiji Hashiba; Kazuyoshi Hirota; Tsuyoshi Kudo; Girolamo Calo'; Remo Guerrini; Akitomo Matsuki
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-03-08       Impact factor: 3.000

10.  Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.

Authors:  Céline Rouget; Yong Yao Cui; Bruno D'Agostino; Christophe Faisy; Emmanuel Naline; Marc Bardou; Charles Advenier
Journal:  Br J Pharmacol       Date:  2004-03-01       Impact factor: 8.739
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