Literature DB >> 10401549

Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus.

A Fischer1, B J Undem.   

Abstract

The recently identified endogenous agonists on the mu-opioid-receptor (mu OR), endomorphin-1 (EM-1) and endomorphin-2 (EM-2), induce a concentration dependent inhibition of electrical field stimulation (EFS)-induced tachykinin-mediated contractions of the guinea-pig bronchus (ED50s < 10 nM for both compounds). Surprisingly, only endomorphin-1 effects could be blocked by naloxone (10 microM), whereas endomorphin-2 effects were not affected by specific antagonists for the mu-, kappa-, and delta-opioid-receptor.

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Year:  1999        PMID： 10401549      PMCID： PMC1566076          DOI： 10.1038/sj.bjp.0702630

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  15 in total

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2.  Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus.

Authors:  A Fischer; W G Forssmann; B J Undem
Journal:  J Pharmacol Exp Ther       Date:  1998-05       Impact factor: 4.030

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Journal:  Nature       Date:  1997-04-03       Impact factor: 49.962

5.  Inhibition of neurally mediated nonadrenergic, noncholinergic contractions of guinea pig bronchus by isozyme-selective phosphodiesterase inhibitors.

Authors:  B J Undem; S N Meeker; J Chen
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6.  Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea.

Authors:  J L Ellis; B J Undem
Journal:  J Pharmacol Exp Ther       Date:  1994-01       Impact factor: 4.030

7.  Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.

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Journal:  Nature       Date:  1995-10-12       Impact factor: 49.962

9.  Evidence that antidromically stimulated vagal afferents activate inhibitory neurones innervating guinea-pig trachealis.

Authors:  B J Canning; B J Undem
Journal:  J Physiol       Date:  1994-11-01       Impact factor: 5.182

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Journal:  Science       Date:  1995-11-03       Impact factor: 47.728
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  1 in total

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  1 in total

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