Literature DB >> 9135821

Gene expression of type II collagens in chondro-osteophytes in experimental osteoarthritis.

J R Matyas1, L J Sandell, M E Adams.   

Abstract

The formation of chondro-osteophytes in osteoarthritic joints is a unique example of adult neochondrogenesis that bears some similarities to growth plate elongation and fracture callus formation. This study uses in situ hybridization histochemistry to define the molecular phenotype of cells in active chondro-osteophytes. Chondro-osteophytes are composed of fibrocytes and osteoblasts that express type I procollagen mRNA, mesenchymal prechondrochytes that express type IIA procollagen mRNA, and maturing chondrocytes that express type IIB procollagen mRNA. Based on the spatial pattern of gene expression and cytomorphology, the neochondrogenesis associated with chondro-osteophyte formation closely resembles that of healing fracture callus.

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Year:  1997        PMID： 9135821     DOI： 10.1016/s1063-4584(97)80003-9

Source DB:  PubMed          Journal:  Osteoarthritis Cartilage        ISSN： 1063-4584            Impact factor:   6.576


  15 in total

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2.  Outcomes of Surface Replacement Proximal Interphalangeal Joint Arthroplasty Using the Self Locking Finger Joint Implant: Minimum Two Years Follow-up.

Authors:  Issei Komatsu; Yoshiya Arishima; Hirotomo Shibahashi; Toshihito Yamaguchi; Yoshitaka Minamikawa
Journal:  Hand (N Y)       Date:  2017-09-16

3.  Meniscus treatment and age associated with narrower radiographic joint space width 2-3 years after ACL reconstruction: data from the MOON onsite cohort.

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Journal:  Osteoarthritis Cartilage       Date:  2015-01-03       Impact factor: 6.576

Review 4.  Interpretation of Cartilage Damage at Routine Clinical MRI: How to Match Arthroscopic Findings.

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Review 5.  Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth).

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Journal:  J Toxicol Pathol       Date:  2016-07-29       Impact factor: 1.628

Review 6.  Clinical and radiographic outcomes of meniscus surgery and future targets for biologic intervention: A review of data from the MOON Group.

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7.  PTHrP, PTHr, and FGFR3 are involved in the process of endochondral ossification in human osteophytes.

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Authors:  Allison W Hsia; Armaun J Emami; Franklin D Tarke; Hailey C Cunningham; Priscilla M Tjandra; Alice Wong; Blaine A Christiansen; Nicole M Collette
Journal:  J Orthop Res       Date:  2017-11-22       Impact factor: 3.494

9.  Surface Replacement Arthroplasty Using a Volar Approach for Osteoarthritis of Proximal Interphalangeal Joint: Results After a Minimum 5-Year Follow-up.

Authors:  Ken Shirakawa; Masahiko Shirota
Journal:  Hand (N Y)       Date:  2018-07-17

10.  Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray.

Authors:  RongKai Zhang; Hang Fang; YuXian Chen; Jun Shen; HuaDing Lu; Chun Zeng; JianHua Ren; Hua Zeng; Zhifu Li; ShaoMing Chen; DaoZhang Cai; Qing Zhao
Journal:  PLoS One       Date:  2012-02-27       Impact factor: 3.240
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