Literature DB >> 9133442

Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.

E M Joseph1, D A Melton.   

Abstract

We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.

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Year:  1997        PMID： 9133442     DOI： 10.1006/dbio.1997.8510

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


  30 in total

1.  Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements.

Authors:  D P Norris; E J Robertson
Journal:  Genes Dev       Date:  1999-06-15       Impact factor: 11.361

Review 2.  The establishment of Spemann's organizer and patterning of the vertebrate embryo.

Authors:  E M De Robertis; J Larraín; M Oelgeschläger; O Wessely
Journal:  Nat Rev Genet       Date:  2000-12       Impact factor: 53.242

3.  Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus.

Authors:  O Wessely; E Agius; M Oelgeschläger; E M Pera; E M De Robertis
Journal:  Dev Biol       Date:  2001-06-01       Impact factor: 3.582

4.  FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development.

Authors:  Aaron B Steiner; Mark J Engleka; Qun Lu; Eileen C Piwarzyk; Sergey Yaklichkin; Julie L Lefebvre; James W Walters; Liliam Pineda-Salgado; Patricia A Labosky; Daniel S Kessler
Journal:  Development       Date:  2006-11-08       Impact factor: 6.868

Review 5.  Understanding how morphogens work.

Authors:  J C Smith; A Hagemann; Y Saka; P H Williams
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2008-04-12       Impact factor: 6.237

Review 6.  Nodal morphogens.

Authors:  Alexander F Schier
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-11       Impact factor: 10.005

Review 7.  Forming and interpreting gradients in the early Xenopus embryo.

Authors:  James C Smith
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-07       Impact factor: 10.005

8.  Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline.

Authors:  M Matsui; K Mizuseki; J Nakatani; S Nakanishi; Y Sasai
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

9.  Rab5-mediated endocytosis of activin is not required for gene activation or long-range signalling in Xenopus.

Authors:  Anja I Hagemann; Xin Xu; Oliver Nentwich; Marko Hyvonen; James C Smith
Journal:  Development       Date:  2009-07-15       Impact factor: 6.868

10.  BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development.

Authors:  Y Cui; F Jean; G Thomas; J L Christian
Journal:  EMBO J       Date:  1998-08-17       Impact factor: 11.598
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