Literature DB >> 20066122

Nodal morphogens.

Alexander F Schier1.   

Abstract

Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 20066122      PMCID： PMC2773646          DOI： 10.1101/cshperspect.a003459

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  203 in total

1.  The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. .

Authors:  M Faucourt; E Houliston; L Besnardeau; D Kimelman; T Lepage
Journal:  Dev Biol       Date:  2001-01-15       Impact factor: 3.582

2.  A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain.

Authors:  M L Concha; R D Burdine; C Russell; A F Schier; S W Wilson
Journal:  Neuron       Date:  2000-11       Impact factor: 17.173

3.  Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.

Authors:  Masamichi Yamamoto; Naoki Mine; Kyoko Mochida; Yasuo Sakai; Yukio Saijoh; Chikara Meno; Hiroshi Hamada
Journal:  Development       Date:  2003-05       Impact factor: 6.868

4.  Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.

Authors:  R N Bamford; E Roessler; R D Burdine; U Saplakoğlu; J dela Cruz; M Splitt; J A Goodship; J Towbin; P Bowers; G B Ferrero; B Marino; A F Schier; M M Shen; M Muenke; B Casey
Journal:  Nat Genet       Date:  2000-11       Impact factor: 38.330

5.  Activin signalling and response to a morphogen gradient.

Authors:  J B Gurdon; P Harger; A Mitchell; P Lemaire
Journal:  Nature       Date:  1994-10-06       Impact factor: 49.962

6.  A molecular pathway determining left-right asymmetry in chick embryogenesis.

Authors:  M Levin; R L Johnson; C D Stern; M Kuehn; C Tabin
Journal:  Cell       Date:  1995-09-08       Impact factor: 41.582

7.  Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.

Authors:  C Meno; Y Saijoh; H Fujii; M Ikeda; T Yokoyama; M Yokoyama; Y Toyoda; H Hamada
Journal:  Nature       Date:  1996-05-09       Impact factor: 49.962

8.  Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center.

Authors:  S Takahashi; C Yokota; K Takano; K Tanegashima; Y Onuma; J Goto; M Asashima
Journal:  Development       Date:  2000-12       Impact factor: 6.868

9.  Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish.

Authors:  R Toyama; M L O'Connell; C V Wright; M R Kuehn; I B Dawid
Journal:  Development       Date:  1995-02       Impact factor: 6.868

10.  Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.

Authors:  C M Jones; M R Kuehn; B L Hogan; J C Smith; C V Wright
Journal:  Development       Date:  1995-11       Impact factor: 6.868
View more
  117 in total

1.  Nodal expression in the uterus of the mouse is regulated by the embryo and correlates with implantation.

Authors:  Craig B Park; Daniel Dufort
Journal:  Biol Reprod       Date:  2011-01-26       Impact factor: 4.285

Review 2.  Left-right asymmetry in zebrafish.

Authors:  Takaaki Matsui; Yasumasa Bessho
Journal:  Cell Mol Life Sci       Date:  2012-04-19       Impact factor: 9.261

3.  A computational statistics approach for estimating the spatial range of morphogen gradients.

Authors:  Jitendra S Kanodia; Yoosik Kim; Raju Tomer; Zia Khan; Kwanghun Chung; John D Storey; Hang Lu; Philipp J Keller; Stanislav Y Shvartsman
Journal:  Development       Date:  2011-10-17       Impact factor: 6.868

Review 4.  Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis.

Authors:  Peter C Gray; Wylie Vale
Journal:  FEBS Lett       Date:  2012-02-01       Impact factor: 4.124

Review 5.  A new paradigm for animal symmetry.

Authors:  Gábor Holló
Journal:  Interface Focus       Date:  2015-12-06       Impact factor: 3.906

6.  Nodal signalling determines biradial asymmetry in Hydra.

Authors:  Hiroshi Watanabe; Heiko A Schmidt; Anne Kuhn; Stefanie K Höger; Yigit Kocagöz; Nico Laumann-Lipp; Suat Ozbek; Thomas W Holstein
Journal:  Nature       Date:  2014-08-24       Impact factor: 49.962

7.  E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation.

Authors:  Andrea E Wills; Julie C Baker
Journal:  Dev Cell       Date:  2015-02-09       Impact factor: 12.270

8.  Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma.

Authors:  Katharine M Hardy; Luigi Strizzi; Naira V Margaryan; Kanika Gupta; George F Murphy; Richard A Scolyer; Mary J C Hendrix
Journal:  Mol Cancer Res       Date:  2015-03-12       Impact factor: 5.852

9.  Plasticity underlies tumor progression: role of Nodal signaling.

Authors:  Thomas M Bodenstine; Grace S Chandler; Richard E B Seftor; Elisabeth A Seftor; Mary J C Hendrix
Journal:  Cancer Metastasis Rev       Date:  2016-03       Impact factor: 9.264

10.  Age-Dependent Association between Protein Expression of the Embryonic Stem Cell Marker Cripto-1 and Survival of Glioblastoma Patients.

Authors:  Berit B Tysnes; Hege A Satran; Sverre J Mork; Naira V Margaryan; Geir E Eide; Kjell Petersen; Luigi Strizzi; Mary J C Hendrix
Journal:  Transl Oncol       Date:  2013-12-01       Impact factor: 4.243
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.